Erythrosin B is a specific inhibitor of high affinity 3H-ouabain binding and ion transport in rat brain

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Abstract

Recent experiments have suggested that the artificial food dye erythrosin B (Red No. 3) is neuroactive in a variety of preparations. Because of the ionic dependence of some of these effects, its actions on Na,K-ATPase activity were studied using rat brain membranes. Erythrosin B is a potent inhibitor of 3H-ouabain binding and ion flux in synaptosomes. These effects appear to be limited to one site of ligand binding and, possibly, to one form of the ATPase.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalNeuropharmacology
Volume20
Issue number1
DOIs
StatePublished - Jan 1981
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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