Erythropoietin Response to Anemia as a Function of Age

James S. Powers, Sanford B. Krantz, Jerry C. Collins, Karen Meurer, Ann Failinger, Terry Buchholz, Michael Blank, Jerry L. Spivak, Mark Hochberg, Alan Baer, P. Mary Cotes, Eugene Goldwasser

Research output: Contribution to journalArticlepeer-review

Abstract

The erythropoietin (EPO) response to anemia was assessed for 244 subjects aged 1–64 years (mean 45.2 years) and 121 subjects aged 65–94 years (mean 68.3 years). Subjects included non‐anemic individuals as well as those with anemia of various etiologies, excluding renal disease and pregnancy. Significant inverse correlations between serum immunoreactive EPO and hematocrit were noted for both groups. Regression lines failed to show a significantly lower slope or y‐intercept for older compared to younger subjects. EPO levels were not significantly lower for older compared to younger subjects when controlled for hematocrit level. These results suggest that the EPO response to anemia in older subjects is similar to that of younger subjects. 1991 The American Geriatrics Society

Original languageEnglish (US)
Pages (from-to)30-32
Number of pages3
JournalJournal of the American Geriatrics Society
Volume39
Issue number1
DOIs
StatePublished - Jan 1991

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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