Erythropoietin receptor positive circulating progenitor cells and endothelial progenitor cells in patients with different stages of diabetic retinopathy

Liu Mei Hu, Xia Lei, Bo Ma, Yu Zhang, Yan Yan, Ya Lan Wu, Ge Zhi Xu, Wen Ye, Ling Wang, Guo Xu Xu, Guo Tong Xu, Wei Ye Li

Research output: Contribution to journalArticle

Abstract

To investigate the possible involvement of erythropoietin (EPO)/erythropoietin receptor (EPOR) system in neovascularization and vascular regeneration in diabetic retinopathy (DR). EPOR positive circulating progenitor cells (CPCs: CD34+) and endothelial progenitor cells (EPCs: CD34 +KDR+) were assessed by flow cytometry in type 2 diabetic patients with different stages of DR. The cohort consisted of age- and sex-matched control patients without diabetes (n=7), non-proliferative DR (NPDR, n=7), proliferative DR (PDR, n=8), and PDR complicated with diabetic nephropathy (PDR-DN, n=7). The numbers of EPOR+ CPCs and EPOR + EPCs were reduced remarkably in NPDR compared with the control group (both P<0.01), whereas rebounded in PDR and PDR-DN groups in varying degrees. Similar changes were observed in respect of the proportion of EPOR + CPCs in CPCs (NPDR vs. control, P<0.01) and that of EPOR + EPCs in EPCs (NPDR vs. control, P<0.05). Exogenous EPO, mediated via the EPO/EPOR system of EPCs, may alleviate the impaired vascular regeneration in NPDR, whereas it might aggravate retinal neovascularization in PDR due to a rebound of EPOR+ EPCs associated with ischemia.

Original languageEnglish (US)
Pages (from-to)69-76
Number of pages8
JournalChinese Medical Sciences Journal
Volume26
Issue number2
DOIs
StatePublished - Jun 1 2011

Keywords

  • circulating progenitor cells
  • diabetic retinopathy
  • endothelial progenitor cells
  • erythropoietin receptor

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Erythropoietin receptor positive circulating progenitor cells and endothelial progenitor cells in patients with different stages of diabetic retinopathy'. Together they form a unique fingerprint.

  • Cite this