Erythroderma after autologous bone marrow transplantation modified by administration of cyclosporine and interferon gamma for breast cancer

Thomas D. Horn, Viki Altomonte, Georgia Vogelsang, M. John Kennedy

Research output: Contribution to journalArticle

Abstract

Background: Allogeneic graft-versus-host disease is associated with decreased rates of tumor relapse. The addition of interferon gamma to cyclosporine, given to induce graft-versus-host disease after autologous bone marrow transplantation, increases the extent of the cutaneous eruption. Objective: Our purpose was to describe the clinical and histologic cutaneous changes in 10 patients with breast cancer who received interferon gamma to potentiate graft-versus-host disease after autologous bone marrow transplantation modified by cyclosporine. Methods: Ten women receiving autologous bone marrow transplantation modified by the administration of cyclosporine and interferon gamma were observed clinically with sequential biopsy of the skin weekly and at the time of cutaneous eruptions. Results: Erythroderma (stage 3) developed in five women after the first or second administration of interferon gamma. At least one skin biopsy specimen from 7 of the 10 women showed grade 2 changes of graft-versus-host reaction, including all patients with erythroderma. Epidermal intercellular edema was prominent in these specimens with expression of keratinocyte HLA-DR and intercellular adhesion molecule 1. Induction of keratinocyte HLA-DR and intercellular adhesion molecule 1 expression was not observed in specimens from normal skin during administration of interferon gamma. Conclusion: This protocol causes a more widely distributed cutaneous eruption, including erythroderma (50%), than autologous bone marrow transplantation and cyclosporine administration alone (3%). Whether it will affect survival is unknown.

Original languageEnglish (US)
Pages (from-to)413-417
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume34
Issue number3
DOIs
StatePublished - Mar 1996

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'Erythroderma after autologous bone marrow transplantation modified by administration of cyclosporine and interferon gamma for breast cancer'. Together they form a unique fingerprint.

Cite this