Erythrocyte Sodium-Potassium-ATPase and Obesity

Jeffrey S. Flier, Mario de Luise, D. M. Mott, I. Klimes, Steven R. Gambert, Edmund H. Duthie, E. Beutler, P. Sacks, W. Kuhl, M. A. Mir, B. M. Charalambous, K. Morgan

Research output: Contribution to journalLetterpeer-review


To the Editor: The conclusions of the paper by Mir et al. on erythrocyte sodium-potassium-ATPase and sodium transport in obesity (November 19 issue)1 differ from ours.2 Their conclusions are based on two assays — sodium efflux from red cells and sodium-potassium-ATPase activity in erythrocyte-derived vesicles — neither of which was performed in our initial study.2 Because Mir et al. did not in fact attempt to reproduce our study, we believe that caution in the interpretation of apparently discordant results is warranted. These authors cite a coefficient of variance of less than 8 per cent in their measurements of vesicle ATPase,.

Original languageEnglish (US)
Pages (from-to)807-810
Number of pages4
JournalNew England Journal of Medicine
Issue number13
StatePublished - Apr 1 1982

ASJC Scopus subject areas

  • Medicine(all)


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