Abstract
Increased activity of erythrocyte sodium-lithium countertransport is associated with essential hypertension. Sodium-lithium countertransport is highly heritable, but no single gene product mediating the exchange or explaining the association of increased sodium-lithium countertransport activity and hypertension has been identified. We performed a linkage study by using erythrocyte sodium-lithium countertransport as a quantitative phenotype and genome-wide markers at an average resolution of ≈10 cM to identify quantitative trait loci explaining sodium-lithium countertransport activity. A peak LOD score of 2.83 was detected on chromosome 15q at D15S642, a marker previously shown to be linked to blood pressure. Several genes mapped to this region are possible candidates for factors affecting erythrocyte sodium-lithium countertransport and/or blood pressure. Further studies confirming the presence of a quantitative trait locus in this region and evaluating these candidate genes may help explain the association of elevated sodium-lithium countertransport and hypertension.
Original language | English (US) |
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Pages (from-to) | 842-846 |
Number of pages | 5 |
Journal | Hypertension |
Volume | 41 |
Issue number | 3 II |
DOIs | |
State | Published - Mar 1 2003 |
Externally published | Yes |
Keywords
- Erythrocytes
- Genes
- Genetics
- Hypertension, essential
- Membranes
ASJC Scopus subject areas
- Internal Medicine