Erythrocyte sodium-lithium countertransport and blood pressure: A genome-wide linkage study

Alan B. Weder, Maria Carolina Delgado, Xiaofeng Zhu, Lillian Gleiberman, Donghui Kan, Aravinda Chakravarti

Research output: Contribution to journalArticlepeer-review

Abstract

Increased activity of erythrocyte sodium-lithium countertransport is associated with essential hypertension. Sodium-lithium countertransport is highly heritable, but no single gene product mediating the exchange or explaining the association of increased sodium-lithium countertransport activity and hypertension has been identified. We performed a linkage study by using erythrocyte sodium-lithium countertransport as a quantitative phenotype and genome-wide markers at an average resolution of ≈10 cM to identify quantitative trait loci explaining sodium-lithium countertransport activity. A peak LOD score of 2.83 was detected on chromosome 15q at D15S642, a marker previously shown to be linked to blood pressure. Several genes mapped to this region are possible candidates for factors affecting erythrocyte sodium-lithium countertransport and/or blood pressure. Further studies confirming the presence of a quantitative trait locus in this region and evaluating these candidate genes may help explain the association of elevated sodium-lithium countertransport and hypertension.

Original languageEnglish (US)
Pages (from-to)842-846
Number of pages5
JournalHypertension
Volume41
Issue number3 II
DOIs
StatePublished - Mar 1 2003

Keywords

  • Erythrocytes
  • Genes
  • Genetics
  • Hypertension, essential
  • Membranes

ASJC Scopus subject areas

  • Internal Medicine

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