TY - JOUR
T1 - Erythrocyte fatty acid composition of Nepal breast-fed infants
AU - Henjum, Sigrun
AU - Lie, Øyvind
AU - Ulak, Manjeswori
AU - Thorne-Lyman, Andrew L.
AU - Chandyo, Ram K.
AU - Shrestha, Prakash S.
AU - W. Fawzi, Wafaie
AU - Strand, Tor A.
AU - Kjellevold, Marian
N1 - Funding Information:
Acknowledgements We want to thank the children and their families for participating in this study. We are also grateful to the staff at Siddhi Memorial Hospital and the fieldworkers. Funding: Supported by Research Council of Norway (Project No. 172226), and a grant from the GCRieber Funds, South-Eastern Norway Regional Health Authority (Grant No. 2012090) and by the USAID Feed the Future Innovation Laboratory for Nutrition.
Publisher Copyright:
© 2017, Springer-Verlag Berlin Heidelberg.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Purpose: Essential fatty acids play a critical role in the growth and development of infants, but little is known about the fatty acid status of populations in low-income countries. The objective was to describe the fatty acid composition of red blood cells (RBC) in breastfeed Nepali infants and a subsample of their mothers and to identify the main sources of fatty acids in the mother’s diet, as well as the fatty acid composition of breast milk. Methods: RBC fatty acid composition was analyzed in a random sample of 303 infants and 72 mother, along with 68 breastmilk samples. Fatty acid profiles of the most important dietary fat sources were analyzed. Information on mother’s diet and intake of fat was collected by three 24-h dietary recalls. Results: In infant RBC’s, docosahexaenoic acid (DHA) was the main n-3 fatty acid, and arachidonic acid (AA) was the major n-6 fatty acid. Total n-6 PUFA was three times higher than total n-3 PUFA. Height-for-age (HAZ) was positively associated with DHA status and AA status in multivariable models. The concentration of all fatty acids was higher in children, compared to mothers, except Total n-6 PUFA and Linoleic acid (LA) where no differences were found. The mother’s energy intake from fat was 13% and cooking oil (sesame, mustard, soybean or sunflower oil) contributed 52% of the fat intake. Conclusions: RBC-DHA levels in both infants and mother was unexpected high taking into account few dietary DHA sources and the low DHA concentrations in breastmilk.
AB - Purpose: Essential fatty acids play a critical role in the growth and development of infants, but little is known about the fatty acid status of populations in low-income countries. The objective was to describe the fatty acid composition of red blood cells (RBC) in breastfeed Nepali infants and a subsample of their mothers and to identify the main sources of fatty acids in the mother’s diet, as well as the fatty acid composition of breast milk. Methods: RBC fatty acid composition was analyzed in a random sample of 303 infants and 72 mother, along with 68 breastmilk samples. Fatty acid profiles of the most important dietary fat sources were analyzed. Information on mother’s diet and intake of fat was collected by three 24-h dietary recalls. Results: In infant RBC’s, docosahexaenoic acid (DHA) was the main n-3 fatty acid, and arachidonic acid (AA) was the major n-6 fatty acid. Total n-6 PUFA was three times higher than total n-3 PUFA. Height-for-age (HAZ) was positively associated with DHA status and AA status in multivariable models. The concentration of all fatty acids was higher in children, compared to mothers, except Total n-6 PUFA and Linoleic acid (LA) where no differences were found. The mother’s energy intake from fat was 13% and cooking oil (sesame, mustard, soybean or sunflower oil) contributed 52% of the fat intake. Conclusions: RBC-DHA levels in both infants and mother was unexpected high taking into account few dietary DHA sources and the low DHA concentrations in breastmilk.
KW - AA
KW - Breast-fed children
KW - Breastmilk
KW - DHA
KW - Plasma phospholipids
KW - Polyunsaturated fatty acids
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U2 - 10.1007/s00394-017-1384-4
DO - 10.1007/s00394-017-1384-4
M3 - Article
C2 - 28238109
AN - SCOPUS:85013852161
VL - 57
SP - 1003
EP - 1013
JO - European Journal of Nutrition
JF - European Journal of Nutrition
SN - 1436-6207
IS - 3
ER -