Erratum: Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia (Brain (2020) 143 (234-48) DOI: 10.1093/brain/awz350)

International Parkinson's Disease Genomics Consortium (IPDGC), 23andMe Research Team

Research output: Contribution to journalComment/debatepeer-review

Abstract

The authors apologize for an error in the 'Genetic modifiers of age at onset in GBA associated Parkinson's disease cases' section in the Results. The first paragraph should read: Information on age at onset was available for the majority of the IPDGC GBA Parkinson's disease cases [89.9% n = 1353 cases, average = 60.54 years, standard deviation (SD) = 11.42]. Cases with two GBA variants (either homozygous or compound heterozygous, n = 38) had a lower age at onset compared to single variant carriers; however, no statistically significant difference was detected [P = 0.107; linear regression, Beta = -2.93 years, standard error (SE) = 1.82, two GBA variant case average = 56.81, SD = 10.50 versus single GBA variant case average = 60.54, SD = 11.42]. The age at onset of GBA Parkinson's disease cases was significantly lower compared to non-GBA Parkinson's disease cases [linear regression, P = 9.70 * 10-6, Beta = -1.43, SE = 0.324, GBA Parkinson's disease case average (one GBA mutation) = 60.54, SD = 11.42 versus non-GBA case average = 62.06, SD = 12.01]. On average p.N370S cases had the earliest age at onset followed by p.E326K and p.T369M. Of note, the LRRK2 p.G2019S variant was also identified in 14 GBA carriers (nine p.N370S and five p.E326K carriers) and did not seem to influence the age at onset P = 0.44 (linear regression, Beta = 2.41, SE = 3.15, GBA Parkinson's disease LRRK2 p.G2019S carriers average = 63.86, SD = 10.87 versus GBA Parkinson's disease nonLRRK2 p.G2019S average = 60.29, SD = 11.80), which is consistent with previous findings, although power was limited given the small number of included individuals (Yahalom et al., 2019).

Original languageEnglish (US)
Pages (from-to)e33
JournalBrain
Volume143
Issue number3
DOIs
StatePublished - Mar 1 2020

ASJC Scopus subject areas

  • Clinical Neurology

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