Erbium vs. Holmium laser incision of the urethra and bladder neck

Ioannis M. Varkarakis, Takeshi Inagaki, Mohamad E Allaf, Theresa Y. Chan, Craig G. Rogers, Edward James Wright, Nathaniel M. Fried

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The objective of this study is to evaluate in an animal model differences in wound healing and scar formation in healthy urethra and bladder neck incised with the Erbium:YAG and Holmium:YAG lasers. In each of 18 domestic pigs, three 1-cm-long incisions were made, two at the bladder neck and one in the mid-urethra using either the Er:YAG laser (9 pigs) or the Ho:YAG laser (9 pigs). In each laser group, three animals were sacrificed on postoperative (POD) days 0, 6, and 14. Width of collateral damage, as evidenced by coagulation necrosis and granulation tissue at the wound base, and incision depth were evaluated during tissue analysis. Collateral damage with the Er:YAG laser at POD 0, 6 and 14 was 20 ± 5 μm, 900 ± 100 μm, and 430 ± 100 μm, respectively. Damage with the Ho:YAG laser was 660 ± 110 μm, 2280 ± 700 μm, and 1580 ± 250 μm, respectively. The granulation tissue was significantly less (p <0.05) at all time points with the Er:YAG laser. Similarly, incision depths for the two laser groups at days 6 (1100 ± 200 μm vs 1500 ± 300 μm) and 14 (670 ± 140 μm vs 1240 ± 140 μm) were also significantly less (p <0.05) for the Er:YAG laser group, indicating faster healing of the wound created. In this in vivo animal study, incisions in the urethra and bladder neck made with the Er:YAG laser healed faster and with less scar formation than incisions made with the Ho:YAG laser.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsK.E. Bartels, L.S. Bass, W.T.W. Riese, K.W. Gregory, H. Hirschberg
Pages171-175
Number of pages5
Volume5686
DOIs
StatePublished - 2005
EventPhotonic Therapeutics and Diagnostics - San Jose, CA, United States
Duration: Jan 22 2005Jan 25 2005

Other

OtherPhotonic Therapeutics and Diagnostics
CountryUnited States
CitySan Jose, CA
Period1/22/051/25/05

Fingerprint

Holmium
Erbium
Lasers
Animals
Granulation
Tissue
Coagulation

Keywords

  • Bladder neck
  • Erbium
  • Holmium
  • Incision
  • Laser
  • Stricture
  • Urethra

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Varkarakis, I. M., Inagaki, T., Allaf, M. E., Chan, T. Y., Rogers, C. G., Wright, E. J., & Fried, N. M. (2005). Erbium vs. Holmium laser incision of the urethra and bladder neck. In K. E. Bartels, L. S. Bass, W. T. W. Riese, K. W. Gregory, & H. Hirschberg (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 5686, pp. 171-175). [32] https://doi.org/10.1117/12.586357

Erbium vs. Holmium laser incision of the urethra and bladder neck. / Varkarakis, Ioannis M.; Inagaki, Takeshi; Allaf, Mohamad E; Chan, Theresa Y.; Rogers, Craig G.; Wright, Edward James; Fried, Nathaniel M.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / K.E. Bartels; L.S. Bass; W.T.W. Riese; K.W. Gregory; H. Hirschberg. Vol. 5686 2005. p. 171-175 32.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Varkarakis, IM, Inagaki, T, Allaf, ME, Chan, TY, Rogers, CG, Wright, EJ & Fried, NM 2005, Erbium vs. Holmium laser incision of the urethra and bladder neck. in KE Bartels, LS Bass, WTW Riese, KW Gregory & H Hirschberg (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 5686, 32, pp. 171-175, Photonic Therapeutics and Diagnostics, San Jose, CA, United States, 1/22/05. https://doi.org/10.1117/12.586357
Varkarakis IM, Inagaki T, Allaf ME, Chan TY, Rogers CG, Wright EJ et al. Erbium vs. Holmium laser incision of the urethra and bladder neck. In Bartels KE, Bass LS, Riese WTW, Gregory KW, Hirschberg H, editors, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 5686. 2005. p. 171-175. 32 https://doi.org/10.1117/12.586357
Varkarakis, Ioannis M. ; Inagaki, Takeshi ; Allaf, Mohamad E ; Chan, Theresa Y. ; Rogers, Craig G. ; Wright, Edward James ; Fried, Nathaniel M. / Erbium vs. Holmium laser incision of the urethra and bladder neck. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. editor / K.E. Bartels ; L.S. Bass ; W.T.W. Riese ; K.W. Gregory ; H. Hirschberg. Vol. 5686 2005. pp. 171-175
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