Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development

Marco Leu, Elena Bellmunt, Martin Schwander, Isabel Fariñas, Hans Rudolf Brenner, Ulrich Müller

Research output: Contribution to journalReview articlepeer-review

Abstract

Neuregulins and their Erbb receptors have been implicated in neuromuscular synapse formation by regulating gene expression in subsynaptic nuclei. To analyze the function of Erbb2 in this process, we have inactivated the Erbb2 gene in developing muscle fibers by Cre/Lox-mediated gene ablation. Neuromuscular synapses form in the mutant mice, but the synapses are less efficient and contain reduced levels of acetylcholine receptors. Surprisingly, the mutant mice also show proprioceptive defects caused by abnormal muscle spindle development. Sensory Ia afferent neurons establish initial contact with Erbb2-deficient myotubes. However, functional spindles never develop. Taken together, our data suggest that Erbb2 signaling regulates the formation of both neuromuscular synapses and muscle spindles.

Original languageEnglish (US)
Pages (from-to)2291-2301
Number of pages11
JournalDevelopment
Volume130
Issue number11
DOIs
StatePublished - Jun 2003
Externally publishedYes

Keywords

  • Erbb2
  • Mouse
  • Muscle spindle
  • Neuromuscular junction
  • Nrg1
  • Synapse

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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