Equipotent generation of protective antitumor immunity by various methods of dendritic cell loading with whole cell tumor antigens

Laura A. Lambert, Glen R. Gibson, Marybeth Maloney, J. Barth Richard

Research output: Contribution to journalArticle

Abstract

Multiple clinically applicable methods have been used to induce dendritic cells (DCs) to express whole cell tumor antigens, including pulsing DCs with tumor lysate, and mixing DCs with apoptotic or live tumor cells. Herein we demonstrate, using two different tumor systems, that these methods are equipotent inducers of systemic antitumor immunity. Furthermore, tumor lysate pulsed DC vaccines generate more potent antitumor immunity than immunization with irradiated tumor cells plus the classic adjuvant, Corynebacterium parvum.

Original languageEnglish (US)
Pages (from-to)232-236
Number of pages5
JournalJournal of Immunotherapy
Volume24
Issue number3
DOIs
StatePublished - 2001

Keywords

  • Dendritic cells
  • Tumor vaccine

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Cancer Research

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