Equatorial ring-like channels in the Cryptococcus neoformans polysaccharide capsule

Oscar Zaragoza, Erin E. Mcclelland, Andrew Telzak, Arturo Casadevall

Research output: Contribution to journalArticlepeer-review


Under certain conditions, India ink particles can penetrate the capsule of the opportunistic pathogen Cryptococcus neoformans. India ink penetration gave two distinct patterns, one as a ring in the middle of the capsule, and another as a double spot located at opposite poles of the cells. These spots were perpendicularly orientated to the bud. This pattern suggests the existence of a localized structure deep in the capsule that can accumulate large insoluble particles. Although the mechanisms responsible for the assemblage and maintenance of ring-like channels are not understood, their existence deep within the capsule implies a new level of complexity for this enigmatic structure.

Original languageEnglish (US)
Pages (from-to)662-666
Number of pages5
JournalFEMS Yeast Research
Issue number4
StatePublished - Jun 2006


  • Capsule
  • Channel
  • Cryptococcus neoformans
  • India Ink
  • Ring

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

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