TY - CHAP
T1 - Epstein–Barr Virus-Associated Post-transplant Lymphoproliferative Disease
AU - Ambinder, Richard F.
N1 - Publisher Copyright:
© 2021, Springer Nature Switzerland AG.
PY - 2021
Y1 - 2021
N2 - Epstein–Barr virus (EBV) is associated with a variety of malignancies including post-transplant lymphoproliferative disease (PTLD). These include B and T cell lymphomas, epithelial, and mesenchymal tumors. The virus is ubiquitous, transmitted in saliva, and not usually associated with the development of malignancy. PTLD is usually associated with EBV when it occurs soon after the transplant. Measurement of viral DNA in blood, especially plasma, may be useful in the diagnosis of PTLD. Treatment approaches include withdrawal of immunosuppression, monoclonal antibodies or antibody conjugates, cytotoxic chemotherapy, and a variety of virus-specific treatments such as adoptive cellular therapy with EBV-specific T cells. Approaches to prevention include selection of immunosuppressive regimens that minimize the risk. In the future, EBV vaccines may be available for potential transplant recipients.
AB - Epstein–Barr virus (EBV) is associated with a variety of malignancies including post-transplant lymphoproliferative disease (PTLD). These include B and T cell lymphomas, epithelial, and mesenchymal tumors. The virus is ubiquitous, transmitted in saliva, and not usually associated with the development of malignancy. PTLD is usually associated with EBV when it occurs soon after the transplant. Measurement of viral DNA in blood, especially plasma, may be useful in the diagnosis of PTLD. Treatment approaches include withdrawal of immunosuppression, monoclonal antibodies or antibody conjugates, cytotoxic chemotherapy, and a variety of virus-specific treatments such as adoptive cellular therapy with EBV-specific T cells. Approaches to prevention include selection of immunosuppressive regimens that minimize the risk. In the future, EBV vaccines may be available for potential transplant recipients.
KW - Cancer
KW - Epstein–Barr virus (EBV)
KW - Hematologic cell transplant
KW - Lymphoma
KW - Post-transplant lymphoproliferative diseases (PTLD)
KW - Solid organ transplant
UR - http://www.scopus.com/inward/record.url?scp=85096257689&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85096257689&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-57362-1_9
DO - 10.1007/978-3-030-57362-1_9
M3 - Chapter
C2 - 33200367
AN - SCOPUS:85096257689
T3 - Recent Results in Cancer Research
SP - 197
EP - 207
BT - Recent Results in Cancer Research
PB - Springer Science and Business Media Deutschland GmbH
ER -