Epstein-Barr virus and familial Hodgkin's disease

Albert Y. Lin, Douglas W. Kingma, Evelyne T. Lennette, Thomas R. Fears, Jean M. Whitehouse, Richard F Ambinder, Elaine S. Jaffe, Paul H. Levine, Margaret A. Tucker

Research output: Contribution to journalArticle

Abstract

Several studies suggest that the Epstein-Barr virus (EBV) is etiologically linked to Hodgkin's disease (HD). This study was undertaken to examine the role of EBV in familial HD (FHD). Among 60 FHD patients from 27 families with two or more cases per family, we tested available paraffinized tumor tissues from 48 cases by in situ hybridization for EBV-encoded RNA (EBER1) expression. Thirteen of 46 FHD patients (28%) had EBER1 expressed in the Reed-Sternberg cells. Concordance rate of EBV positivity was evaluated among 34 first-degree related pairs from 17 families for which both cases had available paraffinized tumor tissues. Only two of 17 pairs were concordant for EBER1 positivity. There was no excess of positive concordance (P = .18). Serologically, FHD patients had higher geometric mean antibody titers (GMTs) to the viral capsid antigen (VCA) and early antigen D (EA-D). There was no difference in seroprevalence between patients and control groups, nor was there concordance in elevated serology among 15 pairs of first-degree related FHD cases. Young adult unaffected family members (UFM) may not react to ESV in the same way as the general population as evidenced by the lower titer of VCA, although not statistically significant, and significantly lower titers of EA-D, compared with age-matched controls. While EBV might have some role in a subset of HD, lack of concordance of EBER1 expression and EBV serology among the FHD cases in the same family suggest that EBV does not play an important role in FHD.

Original languageEnglish (US)
Pages (from-to)3160-3165
Number of pages6
JournalBlood
Volume88
Issue number8
StatePublished - Oct 15 1996
Externally publishedYes

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Human Herpesvirus 4
Hodgkin Disease
Viruses
Antigens
Viral Antigens
Capsid
Serology
Tumors
Tissue
Reed-Sternberg Cells
Seroepidemiologic Studies
In Situ Hybridization
Young Adult
Neoplasms
RNA
Control Groups
Epstein-Barr virus encoded RNA 1
Antibodies
Population

ASJC Scopus subject areas

  • Hematology

Cite this

Lin, A. Y., Kingma, D. W., Lennette, E. T., Fears, T. R., Whitehouse, J. M., Ambinder, R. F., ... Tucker, M. A. (1996). Epstein-Barr virus and familial Hodgkin's disease. Blood, 88(8), 3160-3165.

Epstein-Barr virus and familial Hodgkin's disease. / Lin, Albert Y.; Kingma, Douglas W.; Lennette, Evelyne T.; Fears, Thomas R.; Whitehouse, Jean M.; Ambinder, Richard F; Jaffe, Elaine S.; Levine, Paul H.; Tucker, Margaret A.

In: Blood, Vol. 88, No. 8, 15.10.1996, p. 3160-3165.

Research output: Contribution to journalArticle

Lin, AY, Kingma, DW, Lennette, ET, Fears, TR, Whitehouse, JM, Ambinder, RF, Jaffe, ES, Levine, PH & Tucker, MA 1996, 'Epstein-Barr virus and familial Hodgkin's disease', Blood, vol. 88, no. 8, pp. 3160-3165.
Lin AY, Kingma DW, Lennette ET, Fears TR, Whitehouse JM, Ambinder RF et al. Epstein-Barr virus and familial Hodgkin's disease. Blood. 1996 Oct 15;88(8):3160-3165.
Lin, Albert Y. ; Kingma, Douglas W. ; Lennette, Evelyne T. ; Fears, Thomas R. ; Whitehouse, Jean M. ; Ambinder, Richard F ; Jaffe, Elaine S. ; Levine, Paul H. ; Tucker, Margaret A. / Epstein-Barr virus and familial Hodgkin's disease. In: Blood. 1996 ; Vol. 88, No. 8. pp. 3160-3165.
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