Epstein-Barr virus and bone marrow transplantation

C. Caldas, R. Ambinder

Research output: Contribution to journalReview article

Abstract

The development of Epstein-Barr virus-associated posttransplantation lymphoproliferative disease correlates with increased viral burden in lymphocytes. Patterns of viral gene expression in tumors are complex and heterogenous. Conventional chemotherapy for posttransplantation lymphoproliferative disease is sometimes associated with long-term disease- free survival. A promising new approach involves adoptive cellular immunotherapy with donor lymphocytes or T-cell lines. Allogeneic bone marrow transplantation has been successful in patients with an inherited lack of immune response to Epstein-Barr virus.

Original languageEnglish (US)
Pages (from-to)102-106
Number of pages5
JournalCurrent opinion in oncology
Volume7
Issue number2
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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