Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane

Monn Monn Myat, Deborah J. Andrew

Research output: Contribution to journalArticlepeer-review

Abstract

Formation of tubes of the correct size and shape is essential for viability of most organisms, yet little is understood of the mechanisms controlling tube morphology. We identified a new allele of hairy in a mutagenesis screen and showed that hairy mutations cause branching and bulging of the normally unbranched salivary tube, in part through prolonged expression of huckebein (hkb). HKB controls polarized cell shape change and apical membrane growth during salivary cell invagination via two downstream target genes, crumbs (crb), a determinant of the apical membrane, and klarsicht (klar), which mediates microtubule-dependent organelle transport. In invaginating salivary cells, crb and klar mediate growth and delivery of apical membrane, respectively, thus regulating the size and shape of the salivary tube.

Original languageEnglish (US)
Pages (from-to)879-891
Number of pages13
JournalCell
Volume111
Issue number6
DOIs
StatePublished - Dec 13 2002

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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