Epithelial ovarian cancer, low malignant potential, and sex cord stromal tumors of the ovary

Ramez N. Eskander, Robert E. Bristow

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Ovarian cancer remains the leading cause of gynecologic cancer death in the USA. Understanding of genetic predisposition, including BRCA mutations and Lynch syndrome has resulted in risk reduction in limited populations although no effective screening exists to date. This chapter explores the epidemiology, risk factors, and genetic predisposition of epithelial ovarian cancer. Additionally, diagnosis, and management algorithms are reviewed, with an emphasis on clinical trials guiding current management. The purpose of surgical cytoreduction is reviewed, and the concept of HIPEC introduced. Less common ovarian neoplasms including low malignant potential tumors, germ cell and sex cord stromal tumors are discussed, with an emphasis on diagnosis and recommended treatment. Lastly, emerging molecularly targeted therapies are emphasized.

Original languageEnglish (US)
Title of host publicationGynecologic Oncology
Subtitle of host publicationA Pocketbook
PublisherSpringer New York
Pages3-53
Number of pages51
ISBN (Electronic)9781493919765
ISBN (Print)9781493919758
DOIs
StatePublished - Jan 1 2015

Keywords

  • Angiogenesis
  • BRCA
  • Chemotherapy
  • Epidemiology
  • Genetics
  • Germ line cancer
  • HIPEC
  • Low malignant potential tumor
  • Ovarian cancer
  • PARP inhibition
  • Sex cord stromal cancer

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Eskander, R. N., & Bristow, R. E. (2015). Epithelial ovarian cancer, low malignant potential, and sex cord stromal tumors of the ovary. In Gynecologic Oncology: A Pocketbook (pp. 3-53). Springer New York. https://doi.org/10.1007/978-1-4939-1976-5_1