Epithelial differentiation in pancreatic development and neoplasia: New niches for nestin and Notch

Steven D. Leach

doi:10.1097/01.mcg.0000155547.83901.a3

Epithelial differentiation in pancreatic development and neoplasia: New niches for nestin and Notch

Steven D. Leach

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

Changes in epithelial differentiation represent a characteristic early feature of human pancreatic cancer. Recent work suggests that many of these changes may reflect a pathologic recapitulation of developmental events. Reflecting this principle, metaplastic and neoplastic pancreatic epithelium appear to share many features in common with embryonic pancreatic epithelium, including reactivation of the Notch signaling pathway. In this review, we summarize recent studies involving regulation of epithelial differentiation in both embryonic and adult pancreas and highlight the role of Notch in regulating an exocrine progenitor pool.

Original language	English (US)
Pages (from-to)	S78-S82
Journal	Journal of clinical gastroenterology
Volume	39
Issue number	4 SUPPL.
DOIs	https://doi.org/10.1097/01.mcg.0000155547.83901.a3
State	Published - Apr 2005
Externally published	Yes

Keywords

Cancer
Embryo
Pancreas
Ptf1
Stem cell

ASJC Scopus subject areas

Gastroenterology

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10.1097/01.mcg.0000155547.83901.a3

Cite this

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title = "Epithelial differentiation in pancreatic development and neoplasia: New niches for nestin and Notch",

abstract = "Changes in epithelial differentiation represent a characteristic early feature of human pancreatic cancer. Recent work suggests that many of these changes may reflect a pathologic recapitulation of developmental events. Reflecting this principle, metaplastic and neoplastic pancreatic epithelium appear to share many features in common with embryonic pancreatic epithelium, including reactivation of the Notch signaling pathway. In this review, we summarize recent studies involving regulation of epithelial differentiation in both embryonic and adult pancreas and highlight the role of Notch in regulating an exocrine progenitor pool.",

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N2 - Changes in epithelial differentiation represent a characteristic early feature of human pancreatic cancer. Recent work suggests that many of these changes may reflect a pathologic recapitulation of developmental events. Reflecting this principle, metaplastic and neoplastic pancreatic epithelium appear to share many features in common with embryonic pancreatic epithelium, including reactivation of the Notch signaling pathway. In this review, we summarize recent studies involving regulation of epithelial differentiation in both embryonic and adult pancreas and highlight the role of Notch in regulating an exocrine progenitor pool.

AB - Changes in epithelial differentiation represent a characteristic early feature of human pancreatic cancer. Recent work suggests that many of these changes may reflect a pathologic recapitulation of developmental events. Reflecting this principle, metaplastic and neoplastic pancreatic epithelium appear to share many features in common with embryonic pancreatic epithelium, including reactivation of the Notch signaling pathway. In this review, we summarize recent studies involving regulation of epithelial differentiation in both embryonic and adult pancreas and highlight the role of Notch in regulating an exocrine progenitor pool.

KW - Cancer

KW - Embryo

KW - Pancreas

KW - Ptf1

KW - Stem cell

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JO - Journal of clinical gastroenterology

JF - Journal of clinical gastroenterology

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ER -

Epithelial differentiation in pancreatic development and neoplasia: New niches for nestin and Notch

Abstract

Keywords

ASJC Scopus subject areas

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