Episodic secretion of opioid activity in human plasma and monkey CSF: Evidence for a diurnal rhythm

Dieter Naber, Robert M. Cohen, David Pickar, Ned H. Kalin, Glenn Davis, Candace B. Pert, William E. Bunney

Research output: Contribution to journalArticle

Abstract

Using a radioreceptor assay, opioiod activity has been determined in human plasma and monkey CSF at two-hour intervals across a 24-hour period. In both human plasma and monkey CSF, opioid activity showed an episodic secretion and a significant variation over time, suggesting a diurnal rhythm with increased levels in the morning. This rhythm is similar to those of adrenocorticotropin and beta-lipotropin (LPH) and reciprocal to the diurnal rhythm of pain sensitivity.

Original languageEnglish (US)
Pages (from-to)931-935
Number of pages5
JournalLife Sciences
Volume28
Issue number8
DOIs
StatePublished - Feb 23 1981
Externally publishedYes

Fingerprint

beta-Lipotropin
Plasma (human)
Circadian Rhythm
Human Activities
Opioid Analgesics
Haplorhini
Radioligand Assay
Adrenocorticotropic Hormone
Assays
Pain

ASJC Scopus subject areas

  • Pharmacology

Cite this

Naber, D., Cohen, R. M., Pickar, D., Kalin, N. H., Davis, G., Pert, C. B., & Bunney, W. E. (1981). Episodic secretion of opioid activity in human plasma and monkey CSF: Evidence for a diurnal rhythm. Life Sciences, 28(8), 931-935. https://doi.org/10.1016/0024-3205(81)90056-4

Episodic secretion of opioid activity in human plasma and monkey CSF : Evidence for a diurnal rhythm. / Naber, Dieter; Cohen, Robert M.; Pickar, David; Kalin, Ned H.; Davis, Glenn; Pert, Candace B.; Bunney, William E.

In: Life Sciences, Vol. 28, No. 8, 23.02.1981, p. 931-935.

Research output: Contribution to journalArticle

Naber, D, Cohen, RM, Pickar, D, Kalin, NH, Davis, G, Pert, CB & Bunney, WE 1981, 'Episodic secretion of opioid activity in human plasma and monkey CSF: Evidence for a diurnal rhythm', Life Sciences, vol. 28, no. 8, pp. 931-935. https://doi.org/10.1016/0024-3205(81)90056-4
Naber, Dieter ; Cohen, Robert M. ; Pickar, David ; Kalin, Ned H. ; Davis, Glenn ; Pert, Candace B. ; Bunney, William E. / Episodic secretion of opioid activity in human plasma and monkey CSF : Evidence for a diurnal rhythm. In: Life Sciences. 1981 ; Vol. 28, No. 8. pp. 931-935.
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