Episodic secretion of opioid activity in human plasma and monkey CSF: Evidence for a diurnal rhythm

Dieter Naber, Robert M. Cohen, David Pickar, Ned H. Kalin, Glenn Davis, Candace B. Pert, William E. Bunney

Research output: Contribution to journalArticle

Abstract

Using a radioreceptor assay, opioiod activity has been determined in human plasma and monkey CSF at two-hour intervals across a 24-hour period. In both human plasma and monkey CSF, opioid activity showed an episodic secretion and a significant variation over time, suggesting a diurnal rhythm with increased levels in the morning. This rhythm is similar to those of adrenocorticotropin and beta-lipotropin (LPH) and reciprocal to the diurnal rhythm of pain sensitivity.

Original languageEnglish (US)
Pages (from-to)931-935
Number of pages5
JournalLife Sciences
Volume28
Issue number8
DOIs
StatePublished - Feb 23 1981
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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    Naber, D., Cohen, R. M., Pickar, D., Kalin, N. H., Davis, G., Pert, C. B., & Bunney, W. E. (1981). Episodic secretion of opioid activity in human plasma and monkey CSF: Evidence for a diurnal rhythm. Life Sciences, 28(8), 931-935. https://doi.org/10.1016/0024-3205(81)90056-4