Episodic secretion of opioid activity in human plasma and monkey CSF: Evidence for a diurnal rhythm

Dieter Naber, Robert M. Cohen, David Pickar, Ned H. Kalin, Glenn Davis, Candace B. Pert, William E. Bunney

Research output: Contribution to journalArticlepeer-review

Abstract

Using a radioreceptor assay, opioiod activity has been determined in human plasma and monkey CSF at two-hour intervals across a 24-hour period. In both human plasma and monkey CSF, opioid activity showed an episodic secretion and a significant variation over time, suggesting a diurnal rhythm with increased levels in the morning. This rhythm is similar to those of adrenocorticotropin and beta-lipotropin (LPH) and reciprocal to the diurnal rhythm of pain sensitivity.

Original languageEnglish (US)
Pages (from-to)931-935
Number of pages5
JournalLife Sciences
Volume28
Issue number8
DOIs
StatePublished - Feb 23 1981
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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