Episodic secretion of opioid activity in human plasma and monkey CSF: Evidence for a diurnal rhythm

Dieter Naber; Robert M. Cohen; David Pickar; Ned H. Kalin; Glenn Davis; Candace B. Pert; William E. Bunney

doi:10.1016/0024-3205(81)90056-4

Episodic secretion of opioid activity in human plasma and monkey CSF: Evidence for a diurnal rhythm

Dieter Naber, Robert M. Cohen, David Pickar, Ned H. Kalin, Glenn Davis, Candace B. Pert, William E. Bunney

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Using a radioreceptor assay, opioiod activity has been determined in human plasma and monkey CSF at two-hour intervals across a 24-hour period. In both human plasma and monkey CSF, opioid activity showed an episodic secretion and a significant variation over time, suggesting a diurnal rhythm with increased levels in the morning. This rhythm is similar to those of adrenocorticotropin and beta-lipotropin (LPH) and reciprocal to the diurnal rhythm of pain sensitivity.

Original language	English (US)
Pages (from-to)	931-935
Number of pages	5
Journal	Life Sciences
Volume	28
Issue number	8
DOIs	https://doi.org/10.1016/0024-3205(81)90056-4
State	Published - Feb 23 1981
Externally published	Yes

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0024-3205(81)90056-4

Cite this

@article{8c2aaf07b6144e6aa13c07ac5dc9bf30,

title = "Episodic secretion of opioid activity in human plasma and monkey CSF: Evidence for a diurnal rhythm",

abstract = "Using a radioreceptor assay, opioiod activity has been determined in human plasma and monkey CSF at two-hour intervals across a 24-hour period. In both human plasma and monkey CSF, opioid activity showed an episodic secretion and a significant variation over time, suggesting a diurnal rhythm with increased levels in the morning. This rhythm is similar to those of adrenocorticotropin and beta-lipotropin (LPH) and reciprocal to the diurnal rhythm of pain sensitivity.",

author = "Dieter Naber and Cohen, {Robert M.} and David Pickar and Kalin, {Ned H.} and Glenn Davis and Pert, {Candace B.} and Bunney, {William E.}",

year = "1981",

month = feb,

day = "23",

doi = "10.1016/0024-3205(81)90056-4",

language = "English (US)",

volume = "28",

pages = "931--935",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "8",

}

TY - JOUR

T1 - Episodic secretion of opioid activity in human plasma and monkey CSF

T2 - Evidence for a diurnal rhythm

AU - Naber, Dieter

AU - Cohen, Robert M.

AU - Pickar, David

AU - Kalin, Ned H.

AU - Davis, Glenn

AU - Pert, Candace B.

AU - Bunney, William E.

PY - 1981/2/23

Y1 - 1981/2/23

N2 - Using a radioreceptor assay, opioiod activity has been determined in human plasma and monkey CSF at two-hour intervals across a 24-hour period. In both human plasma and monkey CSF, opioid activity showed an episodic secretion and a significant variation over time, suggesting a diurnal rhythm with increased levels in the morning. This rhythm is similar to those of adrenocorticotropin and beta-lipotropin (LPH) and reciprocal to the diurnal rhythm of pain sensitivity.

AB - Using a radioreceptor assay, opioiod activity has been determined in human plasma and monkey CSF at two-hour intervals across a 24-hour period. In both human plasma and monkey CSF, opioid activity showed an episodic secretion and a significant variation over time, suggesting a diurnal rhythm with increased levels in the morning. This rhythm is similar to those of adrenocorticotropin and beta-lipotropin (LPH) and reciprocal to the diurnal rhythm of pain sensitivity.

UR - http://www.scopus.com/inward/record.url?scp=0019485088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019485088&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(81)90056-4

DO - 10.1016/0024-3205(81)90056-4

M3 - Article

C2 - 7194410

AN - SCOPUS:0019485088

SN - 0024-3205

VL - 28

SP - 931

EP - 935

JO - Life Sciences

JF - Life Sciences

IS - 8

ER -

Episodic secretion of opioid activity in human plasma and monkey CSF: Evidence for a diurnal rhythm

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this