Episodic memory on the path to Alzheimer's disease

Michela Gallagher, Ming Teng Koh

Research output: Contribution to journalReview articlepeer-review


This review is focused on specific circuits of the medial temporal lobe that have become better understood in recent years for their computational properties contributing to episodic memory and to memory impairment associated with aging and other risk for AD. The layer II neurons in the entorhinal cortex and their targets in the dentate gyrus and CA3 region of hippocampus comprise a system that rapidly encodes representations that are distinct from prior memories. Frank neuron loss in the entorhinal cortex is specific for AD, and related structural and functional changes across the network comprised of the entorhinal cortex and the dentate/CA3 regions hold promise for predicting progression on the path to AD.

Original languageEnglish (US)
Pages (from-to)929-934
Number of pages6
JournalCurrent Opinion in Neurobiology
Issue number6
StatePublished - Dec 2011

ASJC Scopus subject areas

  • Neuroscience(all)


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