TY - JOUR
T1 - Episodic memory in dementia
T2 - Characteristics of new learning that differentiate Alzheimer's, Huntington's, and Parkinson's diseases
AU - Aretouli, Eleni
AU - Brandt, Jason
N1 - Funding Information:
This work was supported by grants of the National Institutes of Health to the Johns Hopkins University School of Medicine [P01-NS16375 to the Huntington’s Disease Research Center, P50-AG05146 to the Alzheimer’s Disease Research Center, and P50-NS58377 to the Parkinson’s Disease Research Center].
PY - 2010/8
Y1 - 2010/8
N2 - Differences in the memory characteristics of patients with Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD) were investigated with tests that assess learning and retention of words, line-drawn objects, and locations. Large groups of AD, HD, and PD patients were administered the Hopkins Verbal Learning Test-Revised (HVLT-R) and the Hopkins Board (HB). Eight learning and memory measures were subjected to discriminant function analysis. A 91 classification accuracy was achieved for the separation of cortical and subcortical dementias and 79 accuracy for the discrimination of the three groups. The delayed recall of items was the best discriminator. Receiver-operating curve analysis indicated up to 90 sensitivity and 90 specificity in differentiating the three diseases using the discriminant scores. Individual learning and memory measures of the HVLT-R and the HB provided very high sensitivity and specificity in distinguishing cortical versus subcortical dementias and modest accuracy in separating the two subcortical diseases.
AB - Differences in the memory characteristics of patients with Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD) were investigated with tests that assess learning and retention of words, line-drawn objects, and locations. Large groups of AD, HD, and PD patients were administered the Hopkins Verbal Learning Test-Revised (HVLT-R) and the Hopkins Board (HB). Eight learning and memory measures were subjected to discriminant function analysis. A 91 classification accuracy was achieved for the separation of cortical and subcortical dementias and 79 accuracy for the discrimination of the three groups. The delayed recall of items was the best discriminator. Receiver-operating curve analysis indicated up to 90 sensitivity and 90 specificity in differentiating the three diseases using the discriminant scores. Individual learning and memory measures of the HVLT-R and the HB provided very high sensitivity and specificity in distinguishing cortical versus subcortical dementias and modest accuracy in separating the two subcortical diseases.
KW - Alzheimer's disease
KW - Episodic memory
KW - Huntington's disease
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=77954826113&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954826113&partnerID=8YFLogxK
U2 - 10.1093/arclin/acq038
DO - 10.1093/arclin/acq038
M3 - Article
C2 - 20530592
AN - SCOPUS:77954826113
SN - 0887-6177
VL - 25
SP - 396
EP - 409
JO - Archives of Clinical Neuropsychology
JF - Archives of Clinical Neuropsychology
IS - 5
ER -