Epiretinal membranes in uveitic macular edema: Effect on vision and response to therapy

Brian Lehpamer, Erin Moshier, Patricia Pahk, Naomi Goldberg, Jessica Ackert, James Godbold, Douglas Jabs

Research output: Contribution to journalArticle

Abstract

Purpose To evaluate the effects of epiretinal membranes on the response of uveitic macular edema to therapy and on visual acuity outcomes. Design Retrospective case series. Methods One hundred four eyes of 77 patients with uveitic macular edema were identified at a tertiary care center. Epiretinal membranes were diagnosed when identified by 2 investigators' grading of spectral-domain optical coherence tomography and scored for the presence or absence of surface wrinkling. Outcomes included best-corrected visual acuity, central subfield thickness, and rates of macular edema improvement (>20% reduction in central subfield thickness) and resolution (reduction of central subfield thickness to <315 μm) at 3 and 6 months follow-up. Results Seventy-two eyes of 59 patients had an epiretinal membrane on presentation. Eyes without epiretinal membranes and with epiretinal membranes without surface wrinkling were not significantly different at presentation or at 3 and 6 months follow-up. Conversely, eyes with an epiretinal membrane with retinal surface wrinkling had a greater proportion of eyes with 20/200 or worse visual acuity at presentation, and had worse mean acuities at 3 months (20/94 vs 20/35 for eyes without an epiretinal membrane, P =.002) and at 6 months follow-up (20/110 vs 20/36 for eyes without an epiretinal membrane, P =.02). At 6 months of follow-up the mean central subfield thicknesses were: eyes without an epiretinal membrane, 338 ± 23 μm; and eyes with an epiretinal membrane and surface wrinkling, 405 ± 22 μm (P =.05). Conclusions In eyes with epiretinal membranes and retinal surface wrinkling, uveitic macular edema had a poorer visual acuity response to medical therapy and thicker maculae at 6 months.

Original languageEnglish (US)
Pages (from-to)1048-1055
Number of pages8
JournalAmerican journal of ophthalmology
Volume157
Issue number5
DOIs
StatePublished - Jan 1 2014

Fingerprint

Epiretinal Membrane
Macular Edema
Visual Acuity
Therapeutics
Optical Coherence Tomography
Tertiary Care Centers

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Epiretinal membranes in uveitic macular edema : Effect on vision and response to therapy. / Lehpamer, Brian; Moshier, Erin; Pahk, Patricia; Goldberg, Naomi; Ackert, Jessica; Godbold, James; Jabs, Douglas.

In: American journal of ophthalmology, Vol. 157, No. 5, 01.01.2014, p. 1048-1055.

Research output: Contribution to journalArticle

Lehpamer, Brian ; Moshier, Erin ; Pahk, Patricia ; Goldberg, Naomi ; Ackert, Jessica ; Godbold, James ; Jabs, Douglas. / Epiretinal membranes in uveitic macular edema : Effect on vision and response to therapy. In: American journal of ophthalmology. 2014 ; Vol. 157, No. 5. pp. 1048-1055.
@article{1cbc25187e714ed8978a3391693f6bec,
title = "Epiretinal membranes in uveitic macular edema: Effect on vision and response to therapy",
abstract = "Purpose To evaluate the effects of epiretinal membranes on the response of uveitic macular edema to therapy and on visual acuity outcomes. Design Retrospective case series. Methods One hundred four eyes of 77 patients with uveitic macular edema were identified at a tertiary care center. Epiretinal membranes were diagnosed when identified by 2 investigators' grading of spectral-domain optical coherence tomography and scored for the presence or absence of surface wrinkling. Outcomes included best-corrected visual acuity, central subfield thickness, and rates of macular edema improvement (>20{\%} reduction in central subfield thickness) and resolution (reduction of central subfield thickness to <315 μm) at 3 and 6 months follow-up. Results Seventy-two eyes of 59 patients had an epiretinal membrane on presentation. Eyes without epiretinal membranes and with epiretinal membranes without surface wrinkling were not significantly different at presentation or at 3 and 6 months follow-up. Conversely, eyes with an epiretinal membrane with retinal surface wrinkling had a greater proportion of eyes with 20/200 or worse visual acuity at presentation, and had worse mean acuities at 3 months (20/94 vs 20/35 for eyes without an epiretinal membrane, P =.002) and at 6 months follow-up (20/110 vs 20/36 for eyes without an epiretinal membrane, P =.02). At 6 months of follow-up the mean central subfield thicknesses were: eyes without an epiretinal membrane, 338 ± 23 μm; and eyes with an epiretinal membrane and surface wrinkling, 405 ± 22 μm (P =.05). Conclusions In eyes with epiretinal membranes and retinal surface wrinkling, uveitic macular edema had a poorer visual acuity response to medical therapy and thicker maculae at 6 months.",
author = "Brian Lehpamer and Erin Moshier and Patricia Pahk and Naomi Goldberg and Jessica Ackert and James Godbold and Douglas Jabs",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.ajo.2014.01.020",
language = "English (US)",
volume = "157",
pages = "1048--1055",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "5",

}

TY - JOUR

T1 - Epiretinal membranes in uveitic macular edema

T2 - Effect on vision and response to therapy

AU - Lehpamer, Brian

AU - Moshier, Erin

AU - Pahk, Patricia

AU - Goldberg, Naomi

AU - Ackert, Jessica

AU - Godbold, James

AU - Jabs, Douglas

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose To evaluate the effects of epiretinal membranes on the response of uveitic macular edema to therapy and on visual acuity outcomes. Design Retrospective case series. Methods One hundred four eyes of 77 patients with uveitic macular edema were identified at a tertiary care center. Epiretinal membranes were diagnosed when identified by 2 investigators' grading of spectral-domain optical coherence tomography and scored for the presence or absence of surface wrinkling. Outcomes included best-corrected visual acuity, central subfield thickness, and rates of macular edema improvement (>20% reduction in central subfield thickness) and resolution (reduction of central subfield thickness to <315 μm) at 3 and 6 months follow-up. Results Seventy-two eyes of 59 patients had an epiretinal membrane on presentation. Eyes without epiretinal membranes and with epiretinal membranes without surface wrinkling were not significantly different at presentation or at 3 and 6 months follow-up. Conversely, eyes with an epiretinal membrane with retinal surface wrinkling had a greater proportion of eyes with 20/200 or worse visual acuity at presentation, and had worse mean acuities at 3 months (20/94 vs 20/35 for eyes without an epiretinal membrane, P =.002) and at 6 months follow-up (20/110 vs 20/36 for eyes without an epiretinal membrane, P =.02). At 6 months of follow-up the mean central subfield thicknesses were: eyes without an epiretinal membrane, 338 ± 23 μm; and eyes with an epiretinal membrane and surface wrinkling, 405 ± 22 μm (P =.05). Conclusions In eyes with epiretinal membranes and retinal surface wrinkling, uveitic macular edema had a poorer visual acuity response to medical therapy and thicker maculae at 6 months.

AB - Purpose To evaluate the effects of epiretinal membranes on the response of uveitic macular edema to therapy and on visual acuity outcomes. Design Retrospective case series. Methods One hundred four eyes of 77 patients with uveitic macular edema were identified at a tertiary care center. Epiretinal membranes were diagnosed when identified by 2 investigators' grading of spectral-domain optical coherence tomography and scored for the presence or absence of surface wrinkling. Outcomes included best-corrected visual acuity, central subfield thickness, and rates of macular edema improvement (>20% reduction in central subfield thickness) and resolution (reduction of central subfield thickness to <315 μm) at 3 and 6 months follow-up. Results Seventy-two eyes of 59 patients had an epiretinal membrane on presentation. Eyes without epiretinal membranes and with epiretinal membranes without surface wrinkling were not significantly different at presentation or at 3 and 6 months follow-up. Conversely, eyes with an epiretinal membrane with retinal surface wrinkling had a greater proportion of eyes with 20/200 or worse visual acuity at presentation, and had worse mean acuities at 3 months (20/94 vs 20/35 for eyes without an epiretinal membrane, P =.002) and at 6 months follow-up (20/110 vs 20/36 for eyes without an epiretinal membrane, P =.02). At 6 months of follow-up the mean central subfield thicknesses were: eyes without an epiretinal membrane, 338 ± 23 μm; and eyes with an epiretinal membrane and surface wrinkling, 405 ± 22 μm (P =.05). Conclusions In eyes with epiretinal membranes and retinal surface wrinkling, uveitic macular edema had a poorer visual acuity response to medical therapy and thicker maculae at 6 months.

UR - http://www.scopus.com/inward/record.url?scp=84898848675&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898848675&partnerID=8YFLogxK

U2 - 10.1016/j.ajo.2014.01.020

DO - 10.1016/j.ajo.2014.01.020

M3 - Article

C2 - 24487049

AN - SCOPUS:84898848675

VL - 157

SP - 1048

EP - 1055

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 5

ER -