Patients with lesions treated with radiosurgery frequently present with or later develop seizures. The seizures produced by these lesions are always partial seizures with or without secondary generalization. The acute local tissue reactions produced by radiosurgery may result in transient seizure exacerbation. The medical management and treatment considerations of seizures in these patients during these various periods are discussed. Since virtually all antiepileptic drugs (AED) are effective for the treatment of partial seizures and because comparative trials demonstrating superior efficacy are lacking with the newer agents, often AED selection is based on other considerations.
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