Epilepsy comorbidities: How can animal models help?

Research output: Chapter in Book/Report/Conference proceedingChapter


An epilepsy comorbidity is a condition or disorder that occurs at a frequency greater than chance in a person with epilepsy. Examples of common epilepsy comorbidities are depression, anxiety, and intellectual disability. Epilepsy comorbidities can be quite disabling, sometimes affecting a patient’s quality of life to a greater extent than seizures. Animal models offer the opportunity to explore shared pathophysiological mechanisms, therapeutic options, and consequences of both the epilepsy syndrome and a given comorbidity. In this chapter, depression is used as an example of how animal models can inform translational questions about epilepsy comorbidities.

Original languageEnglish (US)
Title of host publicationIssues in Clinical Epileptology: A View from the Bench
PublisherSpringer New York LLC
Number of pages9
ISBN (Print)9789401789134
Publication statusPublished - 2014
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)00652598
ISSN (Electronic)22148019



  • Animal models
  • Comorbidity
  • Depression
  • Epilepsy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Stafstrom, C. (2014). Epilepsy comorbidities: How can animal models help? In Issues in Clinical Epileptology: A View from the Bench (Vol. 813, pp. 273-281). (Advances in Experimental Medicine and Biology; Vol. 813). Springer New York LLC. https://doi.org/10.1007/978-94-017-8914-1_22