Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis

Huihui Fan, Huda I. Atiya, Yeh Wang, Thomas R. Pisanic, Tza Huei Wang, Ie Ming Shih, Kelly K. Foy, Leonard Frisbie, Ronald J. Buckanovich, Alison A. Chomiak, Rochelle L. Tiedemann, Scott B. Rothbart, Chelsea Chandler, Hui Shen, Lan G. Coffman

Research output: Contribution to journalArticlepeer-review

Abstract

Fan et al. demonstrate that ovarian cancer reprograms the epigenome of stromal cells, inducing a mesenchymal-to-epithelial transition (MET) to form carcinoma-associated mesenchymal stem cells (CA-MSCs). This MET, mediated by WT1 and EZH2, enables CA-MSC:cancer cell co-metastasis. EZH2 inhibition decreases CA-MSC-mediated metastasis, presenting a potential therapeutic opportunity in ovarian cancer.

Original languageEnglish (US)
Article number108473
JournalCell Reports
Volume33
Issue number10
DOIs
StatePublished - Dec 8 2020

Keywords

  • EZH2
  • WT1
  • carcinoma-associated mesenchymal stem cells
  • epigenomic reprogramming
  • mesenchymal-to-epithelial transition
  • metastasis
  • ovarian cancer
  • tumor microenvironment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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