Fan et al. demonstrate that ovarian cancer reprograms the epigenome of stromal cells, inducing a mesenchymal-to-epithelial transition (MET) to form carcinoma-associated mesenchymal stem cells (CA-MSCs). This MET, mediated by WT1 and EZH2, enables CA-MSC:cancer cell co-metastasis. EZH2 inhibition decreases CA-MSC-mediated metastasis, presenting a potential therapeutic opportunity in ovarian cancer.
- carcinoma-associated mesenchymal stem cells
- epigenomic reprogramming
- mesenchymal-to-epithelial transition
- ovarian cancer
- tumor microenvironment
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)