Epigenetics of solid cancer stem cells

Alok Mishra, Mukesh Verma

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epigenetics is an emerging science that can help to explain carcinogenesis. The possibility that carcinogenesis may originate in a stem cell process was proposed recently. Stem cells are generated and contribute to tumor formation during the process of tumor development. This chapter focuses on the role of epigenetics and genetics in stem cell formation, different theories about the origin of cancer stem cells (CSCs), and epigenetic mechanisms that occur in solid CSCs. Potential applications of knowledge gained through this field and future prospects for cancer treatment also are discussed.

Original languageEnglish (US)
Title of host publicationCancer Epigenetics
Subtitle of host publicationMethods and Protocols
Pages15-31
Number of pages17
DOIs
StatePublished - Apr 26 2012
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume863
ISSN (Print)1064-3745

Keywords

  • Biomarker
  • Cancer
  • Differentiation
  • Epigenetic
  • Genetics
  • Histones
  • Methylation
  • MicroRNA
  • Pluripotent
  • Stem cells
  • Tumor

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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