Epigenética en asma

Translated title of the contribution: Epigenetics in asthma

Candelaria Vergara, Jorge Mario Sánchez Caraballo, Beatriz Martínez Alfaro, Luis Caraballo Gracia

Research output: Contribution to journalReview article

Abstract

Asthma is a chronic respiratory disease with a high heritability. It has been postulated that several genes with variable effects are involved in its pathogenesis along with environmental factors. It has been suggested that epigenetic mechanisms can mediate the effects of environmental factors on the onset and progression of the disease. Epigenetics describes inheritable changes in gene expression inherited during meiosis and mitosis that are not encoded in the DNA sequence. They include DNA methylation/ demethylation, acetylation, deacetylation, ubiquitination, SUMOylation and phosphorylation of histones, changes in microARN and alterations of chromatine. In this article we review some findings that establish a relationship between some epigenetic mechanisms and the inflammatory process in asthma and exposure to environmental factors. They include increasing the activity of histone acetyl-transferases and the expression of histone acetylating enzymes, decrease of deacetylating enzymes in the lungs of asthmatics; increased expression of the transcription factor NF-κB in the allergic inflammatory process, changes in methylation/demethlylation of DNA during the differentiation of lymphocytes and the stimulation/suppression of IL-4 and IFNγ genes, respectively. Smoking, bacterial and viral infections, maternal diet and environmental pollution are also factors that trigger epigenetic processes such as histone acetylation and induction of inflammatory cytokines, inactivation of histone deacetytransferases, polarization of the immune response toward the Th2 type and increased production of IgE and cytokines of this profile. We review the epigenetic effects resulting from therapy with corticosteroids and theophylline, and other factors that might influence the risk of asthma in childhood such as maternal intake of fruits, vegetables, fish oils, vitamins, minerals, and the use of probiotics and antibiotics during pregnancy.

Original languageSpanish
Pages (from-to)359-371
Number of pages13
JournalIatreia
Volume22
Issue number4
StatePublished - Dec 1 2009

Fingerprint

Epigenomics
Histones
Asthma
DNA Methylation
Acetylation
Genetic Epigenesis
Mothers
Cytokines
Sumoylation
Environmental Pollution
Plant Oils
Fish Oils
Ubiquitination
Environmental Exposure
Probiotics
Meiosis
Virus Diseases
Enzymes
Theophylline
Lymphocyte Activation

Keywords

  • Allergies
  • Asthma
  • Chromatine
  • Histones
  • Methylation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Vergara, C., Sánchez Caraballo, J. M., Martínez Alfaro, B., & Caraballo Gracia, L. (2009). Epigenética en asma. Iatreia, 22(4), 359-371.

Epigenética en asma. / Vergara, Candelaria; Sánchez Caraballo, Jorge Mario; Martínez Alfaro, Beatriz; Caraballo Gracia, Luis.

In: Iatreia, Vol. 22, No. 4, 01.12.2009, p. 359-371.

Research output: Contribution to journalReview article

Vergara, C, Sánchez Caraballo, JM, Martínez Alfaro, B & Caraballo Gracia, L 2009, 'Epigenética en asma', Iatreia, vol. 22, no. 4, pp. 359-371.
Vergara C, Sánchez Caraballo JM, Martínez Alfaro B, Caraballo Gracia L. Epigenética en asma. Iatreia. 2009 Dec 1;22(4):359-371.
Vergara, Candelaria ; Sánchez Caraballo, Jorge Mario ; Martínez Alfaro, Beatriz ; Caraballo Gracia, Luis. / Epigenética en asma. In: Iatreia. 2009 ; Vol. 22, No. 4. pp. 359-371.
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