Epigenetic Signatures as Biomarkers of Exposure

Research output: Contribution to journalArticle

Abstract

To advance our knowledge of the influence of environmental exposures on human health and disease, robust studies are needed. However, for many exposures, robust studies are not feasible due to limitations with current ascertainment methods and/or study designs. Epigenetics, the study of mitotically heritable, reversible information that regulates critical cell processes, has gained much attention because it offers a potential mechanism to explain how exposures can influence cell states. Therefore, most studies have focused on epigenetics as a mechanism for disease. However, emerging evidence also suggests that epigenetic marks may also serve as biomarkers of exposure. Here, we highlight findings showing that the epigenome is labile to the environment and that these exposure-associated changes show long-term stability, are specific, are detectable in accessible tissues, can predict exposure status, and can be practically implemented, thus supporting the potential for epigenetic patterns to serve as robust measures of environmental exposure.

Original languageEnglish (US)
Pages (from-to)117-125
Number of pages9
JournalCurrent environmental health reports
Volume2
Issue number2
DOIs
StatePublished - Jun 1 2015

Fingerprint

Epigenomics
Biomarkers
Environmental Exposure
Health

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Epigenetic Signatures as Biomarkers of Exposure. / Ladd-Acosta, Christine Marie.

In: Current environmental health reports, Vol. 2, No. 2, 01.06.2015, p. 117-125.

Research output: Contribution to journalArticle

@article{b7aedebef5ed4731a9ae5b1743bd4157,
title = "Epigenetic Signatures as Biomarkers of Exposure",
abstract = "To advance our knowledge of the influence of environmental exposures on human health and disease, robust studies are needed. However, for many exposures, robust studies are not feasible due to limitations with current ascertainment methods and/or study designs. Epigenetics, the study of mitotically heritable, reversible information that regulates critical cell processes, has gained much attention because it offers a potential mechanism to explain how exposures can influence cell states. Therefore, most studies have focused on epigenetics as a mechanism for disease. However, emerging evidence also suggests that epigenetic marks may also serve as biomarkers of exposure. Here, we highlight findings showing that the epigenome is labile to the environment and that these exposure-associated changes show long-term stability, are specific, are detectable in accessible tissues, can predict exposure status, and can be practically implemented, thus supporting the potential for epigenetic patterns to serve as robust measures of environmental exposure.",
author = "Ladd-Acosta, {Christine Marie}",
year = "2015",
month = "6",
day = "1",
doi = "10.1007/s40572-015-0051-2",
language = "English (US)",
volume = "2",
pages = "117--125",
journal = "Current environmental health reports",
issn = "2196-5412",
publisher = "Springer International Publishing AG",
number = "2",

}

TY - JOUR

T1 - Epigenetic Signatures as Biomarkers of Exposure

AU - Ladd-Acosta, Christine Marie

PY - 2015/6/1

Y1 - 2015/6/1

N2 - To advance our knowledge of the influence of environmental exposures on human health and disease, robust studies are needed. However, for many exposures, robust studies are not feasible due to limitations with current ascertainment methods and/or study designs. Epigenetics, the study of mitotically heritable, reversible information that regulates critical cell processes, has gained much attention because it offers a potential mechanism to explain how exposures can influence cell states. Therefore, most studies have focused on epigenetics as a mechanism for disease. However, emerging evidence also suggests that epigenetic marks may also serve as biomarkers of exposure. Here, we highlight findings showing that the epigenome is labile to the environment and that these exposure-associated changes show long-term stability, are specific, are detectable in accessible tissues, can predict exposure status, and can be practically implemented, thus supporting the potential for epigenetic patterns to serve as robust measures of environmental exposure.

AB - To advance our knowledge of the influence of environmental exposures on human health and disease, robust studies are needed. However, for many exposures, robust studies are not feasible due to limitations with current ascertainment methods and/or study designs. Epigenetics, the study of mitotically heritable, reversible information that regulates critical cell processes, has gained much attention because it offers a potential mechanism to explain how exposures can influence cell states. Therefore, most studies have focused on epigenetics as a mechanism for disease. However, emerging evidence also suggests that epigenetic marks may also serve as biomarkers of exposure. Here, we highlight findings showing that the epigenome is labile to the environment and that these exposure-associated changes show long-term stability, are specific, are detectable in accessible tissues, can predict exposure status, and can be practically implemented, thus supporting the potential for epigenetic patterns to serve as robust measures of environmental exposure.

UR - http://www.scopus.com/inward/record.url?scp=84947783202&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947783202&partnerID=8YFLogxK

U2 - 10.1007/s40572-015-0051-2

DO - 10.1007/s40572-015-0051-2

M3 - Article

VL - 2

SP - 117

EP - 125

JO - Current environmental health reports

JF - Current environmental health reports

SN - 2196-5412

IS - 2

ER -