Epigenetic regulation of neurogenesis in the adult mammalian brain

Jiaqi Sun, Jiawei Sun, Guo Li Ming, Hongjun Song

Research output: Contribution to journalArticlepeer-review

Abstract

Epigenetic regulation represents a fundamental mechanism to maintain cell-type-specific gene expression during development and serves as an essential mediator to interface the extrinsic environment and the intrinsic genetic programme. Adult neurogenesis occurs in discrete regions of the adult mammalian brain and is known to be tightly regulated by various physiological, pathological and pharmacological stimuli. Emerging evidence suggests that various epigenetic mechanisms play important roles in fine-tuning and coordinating gene expression during adult neurogenesis. Here we review recent progress in our understanding of various epigenetic mechanisms, including DNA methylation, histone modifications and non-coding RNAs, as well as cross-talk among these mechanisms, in regulating different aspects of adult mammalian neurogenesis.

Original languageEnglish (US)
Pages (from-to)1087-1093
Number of pages7
JournalEuropean Journal of Neuroscience
Volume33
Issue number6
DOIs
StatePublished - Mar 2011

Keywords

  • Adult neural stem cells
  • DNA methylation
  • Histone modifications
  • Non-coding RNAs

ASJC Scopus subject areas

  • Neuroscience(all)

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