Epigenetic regulation of chronic pain

Lingli Liang, Brianna Marie Lutz, Alex Bekker, Yuan Xiang Tao

Research output: Contribution to journalArticle

Abstract

Chronic pain arising from peripheral inflammation and tissue or nerve injury is a common clinical symptom. Although intensive research on the neurobiological mechanisms of chronic pain has been carried out during previous decades, this disorder is still poorly managed by current drugs such as opioids and nonsteroidal anti-inflammatory drugs. Inflammation, tissue injury and/or nerve injury-induced changes in gene expression in sensory neurons of the dorsal root ganglion, spinal cord dorsal horn and pain-associated brain regions are thought to participate in chronic pain genesis; however, how these changes occur is still elusive. Epigenetic modifications including DNA methylation and covalent histone modifications control gene expression. Recent studies have shown that peripheral noxious stimulation changes DNA methylation and histone modifications and that these changes may be related to the induction of pain hypersensitivity under chronic pain conditions. This review summarizes the current knowledge and progress in epigenetic research in chronic pain and discusses the potential role of epigenetic modifications as therapeutic antinociceptive targets in this disorder.

Original languageEnglish (US)
Pages (from-to)235-242
Number of pages8
JournalEpigenomics
Volume7
Issue number2
DOIs
StatePublished - Apr 1 2015
Externally publishedYes

Fingerprint

Epigenomics
Chronic Pain
Histone Code
DNA Methylation
Wounds and Injuries
Inflammation
Gene Expression
Pain
Nerve Tissue
Spinal Ganglia
Sensory Receptor Cells
Research
Pharmaceutical Preparations
Opioid Analgesics
Hypersensitivity
Anti-Inflammatory Agents
Brain
Therapeutics

Keywords

  • chronic pain
  • DNA methylation
  • dorsal root ganglion
  • histone acetylation
  • histone methylation
  • inflammatory pain
  • neuropathic pain
  • spinal cord

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Cite this

Liang, L., Lutz, B. M., Bekker, A., & Tao, Y. X. (2015). Epigenetic regulation of chronic pain. Epigenomics, 7(2), 235-242. https://doi.org/10.2217/epi.14.75

Epigenetic regulation of chronic pain. / Liang, Lingli; Lutz, Brianna Marie; Bekker, Alex; Tao, Yuan Xiang.

In: Epigenomics, Vol. 7, No. 2, 01.04.2015, p. 235-242.

Research output: Contribution to journalArticle

Liang, L, Lutz, BM, Bekker, A & Tao, YX 2015, 'Epigenetic regulation of chronic pain', Epigenomics, vol. 7, no. 2, pp. 235-242. https://doi.org/10.2217/epi.14.75
Liang L, Lutz BM, Bekker A, Tao YX. Epigenetic regulation of chronic pain. Epigenomics. 2015 Apr 1;7(2):235-242. https://doi.org/10.2217/epi.14.75
Liang, Lingli ; Lutz, Brianna Marie ; Bekker, Alex ; Tao, Yuan Xiang. / Epigenetic regulation of chronic pain. In: Epigenomics. 2015 ; Vol. 7, No. 2. pp. 235-242.
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