Epigenetic regulation of axonal regenerative capacity

Yi Lan Weng; Jessica Joseph; Ran An; Hongjun Song; Guo Li Ming

doi:10.2217/epi-2016-0058

Epigenetic regulation of axonal regenerative capacity

Yi Lan Weng, Jessica Joseph, Ran An, Hongjun Song, Guo Li Ming

School of Medicine

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

The intrinsic growth capacity of neurons in the CNS declines during neuronal maturation, while neurons in the adult PNS are capable of regeneration. Injured mature PNS neurons require activation of an array of regeneration-associated genes to regain axonal growth competence. Accumulating evidence indicates a pivotal role of epigenetic mechanisms in transcriptional reprogramming and regulation of neuronal growth ability upon injury. In this review, we summarize the latest findings implicating epigenetic mechanisms, including histone and DNA modifications, in axon regeneration and discuss differential epigenomic configurations between neurons in the adult mammalian CNS and PNS.

Original language	English (US)
Pages (from-to)	1429-1442
Number of pages	14
Journal	Epigenomics
Volume	8
Issue number	10
DOIs	https://doi.org/10.2217/epi-2016-0058
State	Published - Oct 1 2016

Keywords

axon regeneration
DNA demethylation
DNA methylation
DNA methyltransferase
HDAC
histone deacetylase inhibitor
histone modification
TET family protein

ASJC Scopus subject areas

Genetics
Cancer Research

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abstract = "The intrinsic growth capacity of neurons in the CNS declines during neuronal maturation, while neurons in the adult PNS are capable of regeneration. Injured mature PNS neurons require activation of an array of regeneration-associated genes to regain axonal growth competence. Accumulating evidence indicates a pivotal role of epigenetic mechanisms in transcriptional reprogramming and regulation of neuronal growth ability upon injury. In this review, we summarize the latest findings implicating epigenetic mechanisms, including histone and DNA modifications, in axon regeneration and discuss differential epigenomic configurations between neurons in the adult mammalian CNS and PNS.",

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AU - Weng, Yi Lan

AU - Joseph, Jessica

AU - An, Ran

AU - Song, Hongjun

AU - Ming, Guo Li

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Y1 - 2016/10/1

N2 - The intrinsic growth capacity of neurons in the CNS declines during neuronal maturation, while neurons in the adult PNS are capable of regeneration. Injured mature PNS neurons require activation of an array of regeneration-associated genes to regain axonal growth competence. Accumulating evidence indicates a pivotal role of epigenetic mechanisms in transcriptional reprogramming and regulation of neuronal growth ability upon injury. In this review, we summarize the latest findings implicating epigenetic mechanisms, including histone and DNA modifications, in axon regeneration and discuss differential epigenomic configurations between neurons in the adult mammalian CNS and PNS.

AB - The intrinsic growth capacity of neurons in the CNS declines during neuronal maturation, while neurons in the adult PNS are capable of regeneration. Injured mature PNS neurons require activation of an array of regeneration-associated genes to regain axonal growth competence. Accumulating evidence indicates a pivotal role of epigenetic mechanisms in transcriptional reprogramming and regulation of neuronal growth ability upon injury. In this review, we summarize the latest findings implicating epigenetic mechanisms, including histone and DNA modifications, in axon regeneration and discuss differential epigenomic configurations between neurons in the adult mammalian CNS and PNS.

KW - axon regeneration

KW - DNA demethylation

KW - DNA methylation

KW - DNA methyltransferase

KW - HDAC

KW - histone deacetylase inhibitor

KW - histone modification

KW - TET family protein

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Epigenetic regulation of axonal regenerative capacity

Abstract

Keywords

ASJC Scopus subject areas

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