Epigenetic regulation of anterior segment diseases and potential therapeutics

Eric Chen, Kelley Bohm, Mark Rosenblatt, Kai Kang

Research output: Contribution to journalReview articlepeer-review

Abstract

In recent years, technological advances in sequencing have accelerated our understanding of epigenetics in ocular development and ophthalmic diseases. We now know that epigenetic modifications are necessary for normal ocular development and biological processes such as corneal wound healing and ocular surface repair, while aberrant epigenetic regulation underlies the pathogenesis of a wide range of ocular diseases, including cataracts and various diseases of the ocular surface. As the epigenetics of the eye is a constantly changing field of medicine, this comprehensive review focuses on innovations and scientific discoveries related to epigenetic control of anterior segment diseases that were published in the English literature in the past five years. These recent studies attempt to elucidate therapeutic targets for the anterior segment pathological processes. Already, recent studies have shown therapeutic potential in targeting epigenetic mechanisms of ocular diseases, and new epigenetic therapies are on the verge of being introduced to clinical practice. New drug targets can potentially emerge as we make further discoveries within this field.

Original languageEnglish (US)
Pages (from-to)383-395
Number of pages13
JournalOcular Surface
Volume18
Issue number3
DOIs
StatePublished - Jul 2020
Externally publishedYes

Keywords

  • Anterior segment
  • Epigenetics
  • Ophthalmic therapeutics

ASJC Scopus subject areas

  • Ophthalmology

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