Epigenetische processen in de maligne ontaarding: De rol van DNA-methylering in het ontstaan van kanker

Translated title of the contribution: Epigenetic processes in malignant transformation: The role of DNA methylation in cancer development

K. P.M. Suijkerbuijk, E. Van Der Wall, T. Van Laar, M. Vooijs, P. J. Van Diest

Research output: Contribution to journalArticlepeer-review

Abstract

- Defects in DNA that activate oncogenes or inactivate tumour-suppressor genes are regarded as a crucial step in tumour development. - Understanding the processes that modulate gene activity, the so-called epigenetic processes, is gaining importance in the search for factors responsible for uncontrolled cell growth. - Cell proliferation is determined by epigenetic and genetic processes. - Abnormal patterns of methylation and other epigenetic processes, such as acetylation, nucleosome formation and compact chromatin structure, can suppress transcription and inactivate tumour-suppressor genes. - Methylation status is a promising biomarker for malignancy because the process is not patient-specific, it occurs at an early stage of tumour development and may precede morphological changes.

Translated title of the contributionEpigenetic processes in malignant transformation: The role of DNA methylation in cancer development
Original languageDutch
Pages (from-to)907-913
Number of pages7
JournalNederlands Tijdschrift voor Geneeskunde
Volume151
Issue number16
StatePublished - Apr 21 2007

ASJC Scopus subject areas

  • Medicine(all)

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