- Defects in DNA that activate oncogenes or inactivate tumour-suppressor genes are regarded as a crucial step in tumour development. - Understanding the processes that modulate gene activity, the so-called epigenetic processes, is gaining importance in the search for factors responsible for uncontrolled cell growth. - Cell proliferation is determined by epigenetic and genetic processes. - Abnormal patterns of methylation and other epigenetic processes, such as acetylation, nucleosome formation and compact chromatin structure, can suppress transcription and inactivate tumour-suppressor genes. - Methylation status is a promising biomarker for malignancy because the process is not patient-specific, it occurs at an early stage of tumour development and may precede morphological changes.
|Translated title of the contribution||Epigenetic processes in malignant transformation: The role of DNA methylation in cancer development|
|Number of pages||7|
|Journal||Nederlands Tijdschrift voor Geneeskunde|
|State||Published - Apr 21 2007|
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