Epigenetic modifiers synergize with immune-checkpoint blockade to enhance long-lasting antitumor efficacy

Marina Baretti, Mark Yarchoan

Research output: Contribution to journalReview articlepeer-review

Abstract

Immune-checkpoint inhibitors are firmly established as pillars of cancer therapy, but only a minority of cancer patients currently benefit from these therapies, and therapeutic combinations that can enhance responses are urgently needed. Recently, histone deacetylases (HDACs) have emerged as potential targets for immune modulation, but critical questions remain about their mechanisms of action. In this issue of the JCI, Truong et al. assess whether the HDAC inhibitor entinostat can enhance anti–PD-1 treatment in a bladder cancer model. Entinostat promoted a T cell–inflamed phenotype and had substantial antitumor efficacy when used in combination with anti–PD-1 therapy. In addition, the authors showed that HDAC inhibition augmented tumor neoantigen presentation, resulting in the immune editing of tumor antigens. This study highlights a mechanism by which epigenetic modifier agents can synergize with immune-checkpoint blockade for enhanced and long-lasting antitumor activity.

Original languageEnglish (US)
Article numbere151002
JournalJournal of Clinical Investigation
Volume131
Issue number16
DOIs
StatePublished - Aug 16 2021

ASJC Scopus subject areas

  • Medicine(all)

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