Epigenetic epidemiology: Promises for public health research

Kelly M. Bakulski, M. Daniele Fallin

Research output: Contribution to journalReview article

Abstract

Epigenetic changes underlie developmental and age related biology. Promising epidemiologic research implicates epigenetics in disease risk and progression, and suggests epigenetic status depends on environmental risks as well as genetic predisposition. Epigenetics may represent a mechanistic link between environmental exposures, or genetics, and many common diseases, or may simply provide a quantitative biomarker for exposure or disease for areas of epidemiology currently lacking such measures. This great promise is balanced by issues related to study design, measurement tools, statistical methods, and biological interpretation that must be given careful consideration in an epidemiologic setting. This article describes the promises and challenges for epigenetic epidemiology, and suggests directions to advance this emerging area of molecular epidemiology.

Original languageEnglish (US)
Pages (from-to)171-183
Number of pages13
JournalEnvironmental and molecular mutagenesis
Volume55
Issue number3
DOIs
StatePublished - Apr 1 2014

Keywords

  • DNA methylation
  • Disease
  • Environment
  • Epidemiology
  • Epigenetics

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)
  • Health, Toxicology and Mutagenesis

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