Epigenetic effects in eukaryotic gene expression

Timothy H. Bestor, Vicki L. Chandler, Andrew P. Feinberg

Research output: Contribution to journalReview articlepeer-review

Abstract

In the broadest terms, epigenetic phenomena in eukaryotes depend on the interaction of alleles or repeated sequences or on the mitotic inheritance of chromatin states or methylation patterns. One of the most exciting aspects of the study of epigenetic phenomena is the insight that can be gained into the structure and assembly of higher‐order chromatin structures, an important subject that has proved refractory to current biochemical methodologies. Rapid progress in the study of gene inactivation in fungi, plants, and invertebrates will provide new hypotheses to be tested in mammals. © 1994 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)458-462
Number of pages5
JournalDevelopmental Genetics
Volume15
Issue number6
DOIs
StatePublished - 1994

Keywords

  • Epigenetic phenomena
  • chromatin structure
  • eukaryotes

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology

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