Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

John D. Hayes, Albena T. Dinkova-Kostova

Research output: Contribution to journalShort surveypeer-review

Abstract

In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation. In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.

Original languageEnglish (US)
Pages (from-to)5-7
Number of pages3
JournalMolecular Cell
Volume68
Issue number1
DOIs
StatePublished - Oct 5 2017
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions'. Together they form a unique fingerprint.

Cite this