Epigenetic choreographers of neurogenesis in the adult mammalian brain

Dengke K. Ma, Maria Carolina Marchetto, Junjie U. Guo, Guo Li Ming, Fred H. Gage, Hongjun Song

Research output: Contribution to journalArticlepeer-review

233 Scopus citations


Epigenetic mechanisms regulate cell differentiation during embryonic development and also serve as important interfaces between genes and the environment in adulthood. Neurogenesis in adults, which generates functional neural cell types from adult neural stem cells, is dynamically regulated by both intrinsic state-specific cell differentiation cues and extrinsic neural niche signals. Epigenetic regulation by DNA and histone modifiers, non-coding RNAs and other self-sustained mechanisms can lead to relatively long-lasting biological effects and maintain functional neurogenesis throughout life in discrete regions of the mammalian brain. Here, we review recent evidence that epigenetic mechanisms carry out diverse roles in regulating specific aspects of adult neurogenesis and highlight the implications of such epigenetic regulation for neural plasticity and disorders.

Original languageEnglish (US)
Pages (from-to)1338-1344
Number of pages7
JournalNature Neuroscience
Issue number11
StatePublished - Nov 2010

ASJC Scopus subject areas

  • Neuroscience(all)


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