Epigenetic changes in cancer

Christine A. Iacobuzio-Donahue

Research output: Contribution to journalArticle

Abstract

Cancer is as much an epigenetic disease as it is a genetic disease, and epigenetic alterations in cancer often serve as potent surrogates for genetic mutations. Normal epigenetic modifications of DNA encompass three types of changes: chromatin modifications, DNA methylation, and genomic imprinting, each of which is altered in cancer cells. This review addresses the various epigenetic modifications that are pervasive among human tumors and traces the history of cancer epigenetics from the first observations of altered global methylation content to the recently proposed epigenetic progenitor model, which provides a common unifying mechanism for cancer development.

Original languageEnglish (US)
Pages (from-to)229-249
Number of pages21
JournalAnnual Review of Pathology: Mechanisms of Disease
Volume4
DOIs
StatePublished - Feb 2009

Fingerprint

Epigenomics
epigenetics
neoplasms
Neoplasms
Genomic Imprinting
Inborn Genetic Diseases
genomic imprinting
genetic disorders
DNA methylation
DNA Methylation
methylation
Methylation
Chromatin
chromatin
History
mutation
history
Mutation
DNA

Keywords

  • Chromatin
  • Genetics
  • Histone modification
  • Imprinting
  • Methylation
  • Progenitor cell

ASJC Scopus subject areas

  • Plant Science
  • Medicine(all)

Cite this

Epigenetic changes in cancer. / Iacobuzio-Donahue, Christine A.

In: Annual Review of Pathology: Mechanisms of Disease, Vol. 4, 02.2009, p. 229-249.

Research output: Contribution to journalArticle

Iacobuzio-Donahue, Christine A. / Epigenetic changes in cancer. In: Annual Review of Pathology: Mechanisms of Disease. 2009 ; Vol. 4. pp. 229-249.
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