Epigenetic changes by DNA methylation in chronic and intermittent hypoxia

Jayasri Nanduri; Gregg L. Semenza; Nanduri R. Prabhakar

doi:10.1152/ajplung.00325.2017

Epigenetic changes by DNA methylation in chronic and intermittent hypoxia

Jayasri Nanduri, Gregg L. Semenza, Nanduri R. Prabhakar

School of Medicine

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

DNA methylation of cytosine residues is a well-studied epigenetic change, which regulates gene transcription by altering accessibility for transcription factors. Hypoxia is a pervasive stimulus that affects many physiological processes. The circulatory and respiratory systems adapt to chronic sustained hypoxia, such as that encountered during a high-altitude sojourn. Many people living at sea level experience chronic intermittent hypoxia (IH) due to sleep apnea, which leads to cardiovascular and respiratory maladaptation. This article presents a brief update on emerging evidence suggesting that changes in DNA methylation contribute to pathologies caused by chronic IH and potentially mediate adaptations to chronic sustained hypoxia by affecting the hypoxia-inducible factor (HIF) signaling pathway.

Original language	English (US)
Pages (from-to)	L1096-L1100
Journal	American Journal of Physiology - Lung Cellular and Molecular Physiology
Volume	313
Issue number	6
DOIs	https://doi.org/10.1152/ajplung.00325.2017
State	Published - Dec 2017

Keywords

Antioxidant enzyme
Blood pressure
Carotid body reflex
DNA methyl transferases
Redox state

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine
Physiology (medical)
Cell Biology

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10.1152/ajplung.00325.2017

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title = "Epigenetic changes by DNA methylation in chronic and intermittent hypoxia",

abstract = "DNA methylation of cytosine residues is a well-studied epigenetic change, which regulates gene transcription by altering accessibility for transcription factors. Hypoxia is a pervasive stimulus that affects many physiological processes. The circulatory and respiratory systems adapt to chronic sustained hypoxia, such as that encountered during a high-altitude sojourn. Many people living at sea level experience chronic intermittent hypoxia (IH) due to sleep apnea, which leads to cardiovascular and respiratory maladaptation. This article presents a brief update on emerging evidence suggesting that changes in DNA methylation contribute to pathologies caused by chronic IH and potentially mediate adaptations to chronic sustained hypoxia by affecting the hypoxia-inducible factor (HIF) signaling pathway.",

keywords = "Antioxidant enzyme, Blood pressure, Carotid body reflex, DNA methyl transferases, Redox state",

author = "Jayasri Nanduri and Semenza, {Gregg L.} and Prabhakar, {Nanduri R.}",

note = "Funding Information: This study was supported by National Heart, Lung, and Blood Institute Grant P01-HL-90554. Publisher Copyright: {\textcopyright} 2017 the American Physiological Society.",

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AU - Semenza, Gregg L.

AU - Prabhakar, Nanduri R.

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N2 - DNA methylation of cytosine residues is a well-studied epigenetic change, which regulates gene transcription by altering accessibility for transcription factors. Hypoxia is a pervasive stimulus that affects many physiological processes. The circulatory and respiratory systems adapt to chronic sustained hypoxia, such as that encountered during a high-altitude sojourn. Many people living at sea level experience chronic intermittent hypoxia (IH) due to sleep apnea, which leads to cardiovascular and respiratory maladaptation. This article presents a brief update on emerging evidence suggesting that changes in DNA methylation contribute to pathologies caused by chronic IH and potentially mediate adaptations to chronic sustained hypoxia by affecting the hypoxia-inducible factor (HIF) signaling pathway.

AB - DNA methylation of cytosine residues is a well-studied epigenetic change, which regulates gene transcription by altering accessibility for transcription factors. Hypoxia is a pervasive stimulus that affects many physiological processes. The circulatory and respiratory systems adapt to chronic sustained hypoxia, such as that encountered during a high-altitude sojourn. Many people living at sea level experience chronic intermittent hypoxia (IH) due to sleep apnea, which leads to cardiovascular and respiratory maladaptation. This article presents a brief update on emerging evidence suggesting that changes in DNA methylation contribute to pathologies caused by chronic IH and potentially mediate adaptations to chronic sustained hypoxia by affecting the hypoxia-inducible factor (HIF) signaling pathway.

KW - Antioxidant enzyme

KW - Blood pressure

KW - Carotid body reflex

KW - DNA methyl transferases

KW - Redox state

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Epigenetic changes by DNA methylation in chronic and intermittent hypoxia

Abstract

Keywords

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