@article{64168d4564cb45a68fab476098560c52,
title = "Epigenetic age and lung cancer risk in the CLUE II prospective cohort study",
abstract = "Background: Epigenetic age, a robust marker of biological aging, has been associated with obesity, low-grade inflammation and metabolic diseases. However, few studies have examined associations between different epigenetic age measures and risk of lung cancer, despite great interest in finding biomarkers to assist in risk stratification for lung cancer screening. Methods: A nested case-control study of lung cancer from the CLUE II cohort study was conducted using incidence density sampling with 1:1 matching of controls to lung cancer cases (n = 208 matched pairs). Prediagnostic blood samples were collected in 1989 (CLUE II study baseline) and stored at −70°C. DNA was extracted from buffy coat and DNA methylation levels were measured using Illumina MethylationEPIC BeadChip Arrays. Three epigenetic age acceleration (i.e., biological age is greater than chronological age) measurements (Horvath, Hannum and PhenoAge) were examined in relation to lung cancer risk using conditional logistic regression. Results: We did not observe associations between the three epigenetic age acceleration measurements and risk of lung cancer overall; however, inverse associations for the two Hannum age acceleration measures (intrinsic and extrinsic) were observed in men and among younger participants, but not in women or older participants. We did not observe effect modification by time from blood draw to diagnosis. Conclusion: Findings from this study do not support a positive association between three different biological age acceleration measures and risk of lung cancer.",
keywords = "cohort study, DNA methylation, epigenetic clocks, lung cancer",
author = "Michaud, {Dominique S.} and Mei Chung and Naisi Zhao and Koestler, {Devin C.} and Jiayun Lu and Platz, {Elizabeth A.} and Kelsey, {Karl T.}",
note = "Funding Information: Cancer data were provided by the Maryland Cancer Registry, Center for Cancer Prevention and Control, Maryland Department of Health, with funding from the State of Maryland and the Maryland Cigarette Restitution Fund. The collection and availability of cancer registry data is also supported by the Cooperative Agreement NU58DP006333, funded by the Centers for Disease Control and Prevention. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention or the Department of Health and Human Services. Funding Information: This work was supported by 2018 American Association for Cancer Research (AACR)-Johnson & Johnson Lung Cancer Innovation Science (18-90-52-MICH). DCK is supported by National Cancer Institute (NCI) Cancer Center Support Grant P30 CA168524 and the Kansas Institute for Precision Medicine COBRE, supported by the National Institute of General Medical Science award P20 GM130423. Note: The funders had no role in the design of the study; the collection, analysis, and interpretation of the data; the writing of the manuscript; and the decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} 2023 Michaud et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited",
year = "2023",
doi = "10.18632/aging.204501",
language = "English (US)",
volume = "15",
pages = "617--629",
journal = "Aging",
issn = "1945-4589",
publisher = "US Administration on Aging",
number = "3",
}