Epidermal stem cells in Orthopaedic regenerative medicine

Jin Li, Gehua Zhen, Shin Yi Tsai, Xiaofeng Jia

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


In the last decade, great advances have been made in epidermal stem cell studies at the cellular and molecular level. These studies reported various subpopulations and differentiations existing in the epidermal stem cell. Although controversies and unknown issues remain, epidermal stem cells possess an immune-privileged property in transplantation together with easy accessibility, which is favorable for future clinical application. In this review, we will summarize the biological characteristics of epidermal stem cells, and their potential in orthopedic regenerative medicine. Epidermal stem cells play a critical role via cell replacement, and demonstrate significant translational potential in the treatment of orthopedic injuries and diseases, including treatment for wound healing, peripheral nerve and spinal cord injury, and even muscle and bone remodeling.

Original languageEnglish (US)
Pages (from-to)11626-11642
Number of pages17
JournalInternational journal of molecular sciences
Issue number6
StatePublished - Jun 2013


  • Epidermal stem cells
  • Molecular biology
  • Orthopedic regenerative medicine
  • Peripheral nerve injury
  • Spinal cord injury
  • Wound healing

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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