TY - JOUR
T1 - Epidermal plasminogen activator is abnormal in cutaneous lesions
AU - Jensen, Pamela J.
AU - Baird, Janet
AU - Morioka, Shinji
AU - Lessin, Stuart
AU - Lazarus, Gerald S.
PY - 1988/6
Y1 - 1988/6
N2 - To investigate the role of plasminogen activator (PA) in cutaneous disease, we have used biochemical and immunocyto-chemical techniques to examine PA in normal and lesional skin. In normal human dermis, tissue PA is the predominant PA activity; however, in normal epidermis, urokinase type PA is the predominant PA activity. In contrast, PA activity in epidermis from lesions of patients with a variety of cutaneous diseases was predominantly tissue type enzyme with a much smaller contribution from urokinase. Our patient population included individuals with benign chronic pemphigus, pemphigus vulgaris, pemphigus foliaceous, bullous pemphigoid, or psoriasis. Using rabbit antibody specific for tissue type PA, we have immunocytochemically localized this enzyme in lesions from individuals with the above disorders. Our results indicate that tissue PA is consistently elevated in cutaneous lesions with diverse etiology, pathology, and clinical presentation.
AB - To investigate the role of plasminogen activator (PA) in cutaneous disease, we have used biochemical and immunocyto-chemical techniques to examine PA in normal and lesional skin. In normal human dermis, tissue PA is the predominant PA activity; however, in normal epidermis, urokinase type PA is the predominant PA activity. In contrast, PA activity in epidermis from lesions of patients with a variety of cutaneous diseases was predominantly tissue type enzyme with a much smaller contribution from urokinase. Our patient population included individuals with benign chronic pemphigus, pemphigus vulgaris, pemphigus foliaceous, bullous pemphigoid, or psoriasis. Using rabbit antibody specific for tissue type PA, we have immunocytochemically localized this enzyme in lesions from individuals with the above disorders. Our results indicate that tissue PA is consistently elevated in cutaneous lesions with diverse etiology, pathology, and clinical presentation.
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U2 - 10.1111/1523-1747.ep12461494
DO - 10.1111/1523-1747.ep12461494
M3 - Article
C2 - 3131439
AN - SCOPUS:0023910349
SN - 0022-202X
VL - 90
SP - 777
EP - 782
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 6
ER -