Epidermal Growth Factor-mediated Apoptosis of MDA-MB-468 Human Breast Cancer Cells

Deborah K. Armstrong, Scott H. Kaufmann, Yvonne L. Ottaviano, Yuzo Furuya, Julie A. Buckley, John T. Isaacs, Nancy E. Davidson

Research output: Contribution to journalArticlepeer-review

Abstract

MDA-MB-468 human breast cancer cells lack estrogen receptors, overexpress epidermal growth factor (EGF) receptors, and are growth Inhibited by EGF. We show that treatment of MDA-MB-468 cells with EGF leads to inhibition of cell proliferation, fragmentation of DNA into nucleosomal oligomers, and the development of apoptotic morphology. This treatment is associated with increased expression of c-myc, c-fos, jun family members, and transforming growth factor β1 mRNA and with partial proteolytic cleavage of poly(ADP-ribose) polymerase and lamin B. The observation that EGF can mediate apoptosis in EGF receptor-over-expressing cells has important implications for clinical efforts directed at the EGF receptor.

Original languageEnglish (US)
Pages (from-to)5280-5283
Number of pages4
JournalCancer Research
Volume54
Issue number20
StatePublished - Oct 15 1994

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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