Epidemiology of ulcerative keratitis in Northern California

Bennie H. Jeng, David Gritz, Abha B. Kumar, Douglas S. Holsclaw, Travis C. Porco, Scott D. Smith, John P. Whitcher, Todd P. Margolis, Ira G. Wong

Research output: Contribution to journalArticle

Abstract

Objective: To determine the incidence and associated risk factors for ulcerative keratitis in northern California. Methods: In this large-population, retrospective, cohort study, all medical records with diagnosis coding for corneal ulcers during a consecutive 12-month period were reviewed. Incidence rates were calculated using a dynamic population model. Multivariate relative risk regression was conducted to evaluate potential risk factors for ulcerative keratitis. Results: Within the target population of 1 093 210 patients, 302 developed ulcerative keratitis. The incidence of ulcerative keratitis was 27.6 per 100 000 personyears (95% confidence interval, 24.6-30.9). The incidence of corneal ulceration in contact lens wearers was 130.4 per 100 000 person-years (95% confidence interval, 111.3-151.7), with an adjusted relative risk of 9.31 (7.42-11.7; P<.001) compared with non-contact lens wearers, who had an incidence of ulcerative keratitis of 14.0 per 100 000 person-years (11.7-16.6). Seven of 2944 people known to be infected with human immunodeficiency virus developed ulcerative keratitis, with 5 being contact lens wearers. The incidence of ulcerative keratitis in human immunodeficiency virus-positive patients was 238.1 per 100 000 person-years (95% confidence interval, 95.7-490.5), with an odds ratio of 9.31 (7.42-11.7; P<.001) compared withhumanimmunodeficiency virus-negative patients,whohad an incidence of ulcerative keratitis of 27.1 per 100 000 person-years (24.1-30.3). Conclusions: The incidence of ulcerative keratitis in this population is higher than previously reported. This may be owing to the increasing prevalence of contact lens wear.

Original languageEnglish (US)
Pages (from-to)1022-1028
Number of pages7
JournalArchives of Ophthalmology
Volume128
Issue number8
DOIs
StatePublished - Aug 2010
Externally publishedYes

Fingerprint

Corneal Ulcer
Epidemiology
Incidence
Contact Lenses
Confidence Intervals
HIV
Health Services Needs and Demand
Population Dynamics
Population
Lenses
Medical Records
Cohort Studies
Retrospective Studies
Odds Ratio
Viruses

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Jeng, B. H., Gritz, D., Kumar, A. B., Holsclaw, D. S., Porco, T. C., Smith, S. D., ... Wong, I. G. (2010). Epidemiology of ulcerative keratitis in Northern California. Archives of Ophthalmology, 128(8), 1022-1028. https://doi.org/10.1001/archophthalmol.2010.144

Epidemiology of ulcerative keratitis in Northern California. / Jeng, Bennie H.; Gritz, David; Kumar, Abha B.; Holsclaw, Douglas S.; Porco, Travis C.; Smith, Scott D.; Whitcher, John P.; Margolis, Todd P.; Wong, Ira G.

In: Archives of Ophthalmology, Vol. 128, No. 8, 08.2010, p. 1022-1028.

Research output: Contribution to journalArticle

Jeng, BH, Gritz, D, Kumar, AB, Holsclaw, DS, Porco, TC, Smith, SD, Whitcher, JP, Margolis, TP & Wong, IG 2010, 'Epidemiology of ulcerative keratitis in Northern California', Archives of Ophthalmology, vol. 128, no. 8, pp. 1022-1028. https://doi.org/10.1001/archophthalmol.2010.144
Jeng BH, Gritz D, Kumar AB, Holsclaw DS, Porco TC, Smith SD et al. Epidemiology of ulcerative keratitis in Northern California. Archives of Ophthalmology. 2010 Aug;128(8):1022-1028. https://doi.org/10.1001/archophthalmol.2010.144
Jeng, Bennie H. ; Gritz, David ; Kumar, Abha B. ; Holsclaw, Douglas S. ; Porco, Travis C. ; Smith, Scott D. ; Whitcher, John P. ; Margolis, Todd P. ; Wong, Ira G. / Epidemiology of ulcerative keratitis in Northern California. In: Archives of Ophthalmology. 2010 ; Vol. 128, No. 8. pp. 1022-1028.
@article{63124407ce1544949c7ead9ed24c244c,
title = "Epidemiology of ulcerative keratitis in Northern California",
abstract = "Objective: To determine the incidence and associated risk factors for ulcerative keratitis in northern California. Methods: In this large-population, retrospective, cohort study, all medical records with diagnosis coding for corneal ulcers during a consecutive 12-month period were reviewed. Incidence rates were calculated using a dynamic population model. Multivariate relative risk regression was conducted to evaluate potential risk factors for ulcerative keratitis. Results: Within the target population of 1 093 210 patients, 302 developed ulcerative keratitis. The incidence of ulcerative keratitis was 27.6 per 100 000 personyears (95{\%} confidence interval, 24.6-30.9). The incidence of corneal ulceration in contact lens wearers was 130.4 per 100 000 person-years (95{\%} confidence interval, 111.3-151.7), with an adjusted relative risk of 9.31 (7.42-11.7; P<.001) compared with non-contact lens wearers, who had an incidence of ulcerative keratitis of 14.0 per 100 000 person-years (11.7-16.6). Seven of 2944 people known to be infected with human immunodeficiency virus developed ulcerative keratitis, with 5 being contact lens wearers. The incidence of ulcerative keratitis in human immunodeficiency virus-positive patients was 238.1 per 100 000 person-years (95{\%} confidence interval, 95.7-490.5), with an odds ratio of 9.31 (7.42-11.7; P<.001) compared withhumanimmunodeficiency virus-negative patients,whohad an incidence of ulcerative keratitis of 27.1 per 100 000 person-years (24.1-30.3). Conclusions: The incidence of ulcerative keratitis in this population is higher than previously reported. This may be owing to the increasing prevalence of contact lens wear.",
author = "Jeng, {Bennie H.} and David Gritz and Kumar, {Abha B.} and Holsclaw, {Douglas S.} and Porco, {Travis C.} and Smith, {Scott D.} and Whitcher, {John P.} and Margolis, {Todd P.} and Wong, {Ira G.}",
year = "2010",
month = "8",
doi = "10.1001/archophthalmol.2010.144",
language = "English (US)",
volume = "128",
pages = "1022--1028",
journal = "JAMA Ophthalmology",
issn = "2168-6165",
publisher = "American Medical Association",
number = "8",

}

TY - JOUR

T1 - Epidemiology of ulcerative keratitis in Northern California

AU - Jeng, Bennie H.

AU - Gritz, David

AU - Kumar, Abha B.

AU - Holsclaw, Douglas S.

AU - Porco, Travis C.

AU - Smith, Scott D.

AU - Whitcher, John P.

AU - Margolis, Todd P.

AU - Wong, Ira G.

PY - 2010/8

Y1 - 2010/8

N2 - Objective: To determine the incidence and associated risk factors for ulcerative keratitis in northern California. Methods: In this large-population, retrospective, cohort study, all medical records with diagnosis coding for corneal ulcers during a consecutive 12-month period were reviewed. Incidence rates were calculated using a dynamic population model. Multivariate relative risk regression was conducted to evaluate potential risk factors for ulcerative keratitis. Results: Within the target population of 1 093 210 patients, 302 developed ulcerative keratitis. The incidence of ulcerative keratitis was 27.6 per 100 000 personyears (95% confidence interval, 24.6-30.9). The incidence of corneal ulceration in contact lens wearers was 130.4 per 100 000 person-years (95% confidence interval, 111.3-151.7), with an adjusted relative risk of 9.31 (7.42-11.7; P<.001) compared with non-contact lens wearers, who had an incidence of ulcerative keratitis of 14.0 per 100 000 person-years (11.7-16.6). Seven of 2944 people known to be infected with human immunodeficiency virus developed ulcerative keratitis, with 5 being contact lens wearers. The incidence of ulcerative keratitis in human immunodeficiency virus-positive patients was 238.1 per 100 000 person-years (95% confidence interval, 95.7-490.5), with an odds ratio of 9.31 (7.42-11.7; P<.001) compared withhumanimmunodeficiency virus-negative patients,whohad an incidence of ulcerative keratitis of 27.1 per 100 000 person-years (24.1-30.3). Conclusions: The incidence of ulcerative keratitis in this population is higher than previously reported. This may be owing to the increasing prevalence of contact lens wear.

AB - Objective: To determine the incidence and associated risk factors for ulcerative keratitis in northern California. Methods: In this large-population, retrospective, cohort study, all medical records with diagnosis coding for corneal ulcers during a consecutive 12-month period were reviewed. Incidence rates were calculated using a dynamic population model. Multivariate relative risk regression was conducted to evaluate potential risk factors for ulcerative keratitis. Results: Within the target population of 1 093 210 patients, 302 developed ulcerative keratitis. The incidence of ulcerative keratitis was 27.6 per 100 000 personyears (95% confidence interval, 24.6-30.9). The incidence of corneal ulceration in contact lens wearers was 130.4 per 100 000 person-years (95% confidence interval, 111.3-151.7), with an adjusted relative risk of 9.31 (7.42-11.7; P<.001) compared with non-contact lens wearers, who had an incidence of ulcerative keratitis of 14.0 per 100 000 person-years (11.7-16.6). Seven of 2944 people known to be infected with human immunodeficiency virus developed ulcerative keratitis, with 5 being contact lens wearers. The incidence of ulcerative keratitis in human immunodeficiency virus-positive patients was 238.1 per 100 000 person-years (95% confidence interval, 95.7-490.5), with an odds ratio of 9.31 (7.42-11.7; P<.001) compared withhumanimmunodeficiency virus-negative patients,whohad an incidence of ulcerative keratitis of 27.1 per 100 000 person-years (24.1-30.3). Conclusions: The incidence of ulcerative keratitis in this population is higher than previously reported. This may be owing to the increasing prevalence of contact lens wear.

UR - http://www.scopus.com/inward/record.url?scp=77955459367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955459367&partnerID=8YFLogxK

U2 - 10.1001/archophthalmol.2010.144

DO - 10.1001/archophthalmol.2010.144

M3 - Article

C2 - 20697003

AN - SCOPUS:77955459367

VL - 128

SP - 1022

EP - 1028

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

SN - 2168-6165

IS - 8

ER -