TY - JOUR
T1 - Epidemiology of masked and white-coat hypertension
T2 - The family-based SKIPOGH study
AU - Alwan, Heba
AU - Pruijm, Menno
AU - Ponte, Belen
AU - Ackermann, Daniel
AU - Guessous, Idris
AU - Ehret, Georg
AU - Staessen, Jan A.
AU - Asayama, Kei
AU - Vuistiner, Philippe
AU - Younes, Sandrine Estoppey
AU - Paccaud, Fred
AU - Wuerzner, Grégoire
AU - Pechere-Bertschi, Antoinette
AU - Mohaupt, Markus
AU - Vogt, Bruno
AU - Martin, Pierre Yves
AU - Burnier, Michel
AU - Bochud, Murielle
PY - 2014/3/24
Y1 - 2014/3/24
N2 - Objective: We investigated factors associated with masked and white-coat hypertension in a Swiss population-based sample. Methods: The Swiss Kidney Project on Genes in Hypertension is a family-based cross-sectional study. Office and 24-hour ambulatory blood pressure were measured using validated devices. Masked hypertension was defined as office blood pressure <140/90 mmHg and daytime ambulatory blood pressure≥135/85 mmHg. White-coat hypertension was defined as office blood pressure ≥140/90 mmHg and daytime ambulatory blood pressure<135/85 mmHg. Mixed-effect logistic regression was used to examine the relationship of masked and white-coat hypertension with associated factors, while taking familial correlations into account. High-normal office blood pressure was defined as systolic/diastolic blood pressure within the 130-139/85-89 mmHg range. Results: Among the 652 participants included in this analysis, 51% were female. Mean age (±SD) was 48 (±18) years. The proportion of participants with masked and white coat hypertension was respectively 15.8% and 2.6%. Masked hypertension was associated with age (odds ratio (OR) = 1.02, p = 0.012), high-normal office blood pressure (OR = 6.68, p<0.001), and obesity (OR = 3.63, p = 0.001). White-coat hypertension was significantly associated with age (OR = 1.07, p<0.001) but not with education, family history of hypertension, or physical activity. Conclusions: Our findings suggest that physicians should consider ambulatory blood pressure monitoring for older individuals with high-normal office blood pressure and/or who are obese.
AB - Objective: We investigated factors associated with masked and white-coat hypertension in a Swiss population-based sample. Methods: The Swiss Kidney Project on Genes in Hypertension is a family-based cross-sectional study. Office and 24-hour ambulatory blood pressure were measured using validated devices. Masked hypertension was defined as office blood pressure <140/90 mmHg and daytime ambulatory blood pressure≥135/85 mmHg. White-coat hypertension was defined as office blood pressure ≥140/90 mmHg and daytime ambulatory blood pressure<135/85 mmHg. Mixed-effect logistic regression was used to examine the relationship of masked and white-coat hypertension with associated factors, while taking familial correlations into account. High-normal office blood pressure was defined as systolic/diastolic blood pressure within the 130-139/85-89 mmHg range. Results: Among the 652 participants included in this analysis, 51% were female. Mean age (±SD) was 48 (±18) years. The proportion of participants with masked and white coat hypertension was respectively 15.8% and 2.6%. Masked hypertension was associated with age (odds ratio (OR) = 1.02, p = 0.012), high-normal office blood pressure (OR = 6.68, p<0.001), and obesity (OR = 3.63, p = 0.001). White-coat hypertension was significantly associated with age (OR = 1.07, p<0.001) but not with education, family history of hypertension, or physical activity. Conclusions: Our findings suggest that physicians should consider ambulatory blood pressure monitoring for older individuals with high-normal office blood pressure and/or who are obese.
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U2 - 10.1371/journal.pone.0092522
DO - 10.1371/journal.pone.0092522
M3 - Article
C2 - 24663506
AN - SCOPUS:84899723697
SN - 1932-6203
VL - 9
JO - PloS one
JF - PloS one
IS - 3
M1 - e92522
ER -