Epidemiology of masked and white-coat hypertension: The family-based SKIPOGH study

Heba Alwan, Menno Pruijm, Belen Ponte, Daniel Ackermann, Idris Guessous, Georg Ehret, Jan A. Staessen, Kei Asayama, Philippe Vuistiner, Sandrine Estoppey Younes, Fred Paccaud, Grégoire Wuerzner, Antoinette Pechere-Bertschi, Markus Mohaupt, Bruno Vogt, Pierre Yves Martin, Michel Burnier, Murielle Bochud

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: We investigated factors associated with masked and white-coat hypertension in a Swiss population-based sample. Methods: The Swiss Kidney Project on Genes in Hypertension is a family-based cross-sectional study. Office and 24-hour ambulatory blood pressure were measured using validated devices. Masked hypertension was defined as office blood pressure <140/90 mmHg and daytime ambulatory blood pressure≥135/85 mmHg. White-coat hypertension was defined as office blood pressure ≥140/90 mmHg and daytime ambulatory blood pressure<135/85 mmHg. Mixed-effect logistic regression was used to examine the relationship of masked and white-coat hypertension with associated factors, while taking familial correlations into account. High-normal office blood pressure was defined as systolic/diastolic blood pressure within the 130-139/85-89 mmHg range. Results: Among the 652 participants included in this analysis, 51% were female. Mean age (±SD) was 48 (±18) years. The proportion of participants with masked and white coat hypertension was respectively 15.8% and 2.6%. Masked hypertension was associated with age (odds ratio (OR) = 1.02, p = 0.012), high-normal office blood pressure (OR = 6.68, p<0.001), and obesity (OR = 3.63, p = 0.001). White-coat hypertension was significantly associated with age (OR = 1.07, p<0.001) but not with education, family history of hypertension, or physical activity. Conclusions: Our findings suggest that physicians should consider ambulatory blood pressure monitoring for older individuals with high-normal office blood pressure and/or who are obese.

Original languageEnglish (US)
Article numbere92522
JournalPloS one
Volume9
Issue number3
DOIs
StatePublished - Mar 24 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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