TY - JOUR
T1 - Epidemiology of invasive group A Streptococcus disease in the United States, 1995-1999
AU - O’Brien, Katherine L.
AU - Beall, Bernard
AU - Barrett, Nancy L.
AU - Cieslak, Paul R.
AU - Reingold, Arthur
AU - Farley, Monica M.
AU - Danila, Richard
AU - Zell, Elizabeth R.
AU - Facklam, Richard
AU - Schwartz, Benjamin
AU - Schuchat, Anne
PY - 2002/8/1
Y1 - 2002/8/1
N2 - Severe invasive group A streptococcal (GAS) disease is believed to have reemerged during the past 10-20 years. We conducted active, laboratory, population-based surveillance in 5 US states (total population, 13,214,992). From 1 July 1995 through 31 December 1999, we identified 2002 episodes of invasive GAS (3.5 cases per 100,000 persons). Rates varied by age (higher among those <2 or ≥65 years old), surveillance area, and race (higher among black individuals) but did not increase during the study period. The 5 most common emm types (1, 28, 12, 3, and 11) accounted for 49.2% of isolates; newly characterized emm types accounted for 8.9% of isolates. Older age; presence of streptococcal toxic shock syndrome, meningitis, or pneumonia; and infection with emm1 or emm3 were all independent predictors of death. We estimate that 9600-9700 cases of invasive GAS disease occur in the United States each year, resulting in 1100-1300 deaths.
AB - Severe invasive group A streptococcal (GAS) disease is believed to have reemerged during the past 10-20 years. We conducted active, laboratory, population-based surveillance in 5 US states (total population, 13,214,992). From 1 July 1995 through 31 December 1999, we identified 2002 episodes of invasive GAS (3.5 cases per 100,000 persons). Rates varied by age (higher among those <2 or ≥65 years old), surveillance area, and race (higher among black individuals) but did not increase during the study period. The 5 most common emm types (1, 28, 12, 3, and 11) accounted for 49.2% of isolates; newly characterized emm types accounted for 8.9% of isolates. Older age; presence of streptococcal toxic shock syndrome, meningitis, or pneumonia; and infection with emm1 or emm3 were all independent predictors of death. We estimate that 9600-9700 cases of invasive GAS disease occur in the United States each year, resulting in 1100-1300 deaths.
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U2 - 10.1086/341409
DO - 10.1086/341409
M3 - Article
C2 - 12115092
AN - SCOPUS:0036680109
SN - 1058-4838
VL - 35
SP - 268
EP - 276
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 3
ER -