Epidemiology of Human Papillomavirus-Related Head and Neck Cancer

Andrew W. Joseph; Gypsyamber D'Souza

doi:10.1016/j.otc.2012.04.003

Epidemiology of Human Papillomavirus-Related Head and Neck Cancer

Andrew W. Joseph, Gypsyamber D'Souza

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

Abstract

Human papillomavirus (HPV) is now recognized to cause a subset of head and neck squamous cell carcinomas (HNSCC). Although excessive tobacco and alcohol use continue to be important risk factors for HNSCC, epidemiologic studies suggest that more than 25% of HNSCC are now caused by HPV. The incidence of HPV-related HNSCC is increasing, highlighting the need to understand the oral HPV infections causing these cancers. This article reviews the evidence for a causal association between HPV and HNSCC, examines the changing epidemiologic trends of HNSCC, and discusses what is currently known about oral HPV infection, natural history, and transmission.

Original language	English (US)
Pages (from-to)	739-764
Number of pages	26
Journal	Otolaryngologic Clinics of North America
Volume	45
Issue number	4
DOIs	https://doi.org/10.1016/j.otc.2012.04.003
State	Published - Aug 1 2012

Keywords

Epidemiology
HPV
Head and neck cancer
Human papillomavirus
Oropharyngeal cancer
Squamous cell carcinoma

ASJC Scopus subject areas

Otorhinolaryngology

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Cite this

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title = "Epidemiology of Human Papillomavirus-Related Head and Neck Cancer",

abstract = "Human papillomavirus (HPV) is now recognized to cause a subset of head and neck squamous cell carcinomas (HNSCC). Although excessive tobacco and alcohol use continue to be important risk factors for HNSCC, epidemiologic studies suggest that more than 25% of HNSCC are now caused by HPV. The incidence of HPV-related HNSCC is increasing, highlighting the need to understand the oral HPV infections causing these cancers. This article reviews the evidence for a causal association between HPV and HNSCC, examines the changing epidemiologic trends of HNSCC, and discusses what is currently known about oral HPV infection, natural history, and transmission.",

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AU - D'Souza, Gypsyamber

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N2 - Human papillomavirus (HPV) is now recognized to cause a subset of head and neck squamous cell carcinomas (HNSCC). Although excessive tobacco and alcohol use continue to be important risk factors for HNSCC, epidemiologic studies suggest that more than 25% of HNSCC are now caused by HPV. The incidence of HPV-related HNSCC is increasing, highlighting the need to understand the oral HPV infections causing these cancers. This article reviews the evidence for a causal association between HPV and HNSCC, examines the changing epidemiologic trends of HNSCC, and discusses what is currently known about oral HPV infection, natural history, and transmission.

AB - Human papillomavirus (HPV) is now recognized to cause a subset of head and neck squamous cell carcinomas (HNSCC). Although excessive tobacco and alcohol use continue to be important risk factors for HNSCC, epidemiologic studies suggest that more than 25% of HNSCC are now caused by HPV. The incidence of HPV-related HNSCC is increasing, highlighting the need to understand the oral HPV infections causing these cancers. This article reviews the evidence for a causal association between HPV and HNSCC, examines the changing epidemiologic trends of HNSCC, and discusses what is currently known about oral HPV infection, natural history, and transmission.

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KW - Human papillomavirus

KW - Oropharyngeal cancer

KW - Squamous cell carcinoma

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