Epidemiology of Human Papillomavirus-Related Head and Neck Cancer

Andrew W. Joseph, Gypsyamber D'Souza

Research output: Contribution to journalReview articlepeer-review


Human papillomavirus (HPV) is now recognized to cause a subset of head and neck squamous cell carcinomas (HNSCC). Although excessive tobacco and alcohol use continue to be important risk factors for HNSCC, epidemiologic studies suggest that more than 25% of HNSCC are now caused by HPV. The incidence of HPV-related HNSCC is increasing, highlighting the need to understand the oral HPV infections causing these cancers. This article reviews the evidence for a causal association between HPV and HNSCC, examines the changing epidemiologic trends of HNSCC, and discusses what is currently known about oral HPV infection, natural history, and transmission.

Original languageEnglish (US)
Pages (from-to)739-764
Number of pages26
JournalOtolaryngologic Clinics of North America
Issue number4
StatePublished - Aug 1 2012


  • Epidemiology
  • HPV
  • Head and neck cancer
  • Human papillomavirus
  • Oropharyngeal cancer
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology


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