Epidemiology of human papillomavirus-positive head and neck squamous cell carcinoma

Maura L. Gillison, Anil K. Chaturvedi, William F. Anderson, Carole Fakhry

Research output: Contribution to journalArticle

Abstract

Human papillomavirus (HPV) is now established as the principal cause of an increase in incidence of a subset of head and neck squamous cell cancers (HNCs) in numerous geographic regions around the world. Further study of the epidemiology of HPV-positive HNC will be critical to the development and implementation of public health interventions to reverse these global incidence trends. Here, recent data are reviewed to provide insight into several topics, including incidence trends and projections for HPV-positive HNC; the worldwide HPV-attributable fraction; sex disparities in cancer risk; the epidemiology of oral HPV infection; the latency period between infection and cancer; the potential impact of prophylactic HPV vaccination; and prospects for secondary prevention through screening for oral HPV infection or seroreactivity to viral antigens. The identification of a single necessary cause for any cancer provides a rare and perhaps extraordinary opportunity for cancer prevention.

LanguageEnglish (US)
Pages3235-3242
Number of pages8
JournalJournal of Clinical Oncology
Volume33
Issue number29
DOIs
StatePublished - Oct 10 2015

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Epidemiology
Squamous Cell Neoplasms
Head and Neck Neoplasms
Papillomavirus Infections
Head
Neoplasms
Incidence
Viral Antigens
Secondary Prevention
Carcinoma, squamous cell of head and neck
Vaccination
Public Health
Infection

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Epidemiology of human papillomavirus-positive head and neck squamous cell carcinoma. / Gillison, Maura L.; Chaturvedi, Anil K.; Anderson, William F.; Fakhry, Carole.

In: Journal of Clinical Oncology, Vol. 33, No. 29, 10.10.2015, p. 3235-3242.

Research output: Contribution to journalArticle

Gillison, Maura L. ; Chaturvedi, Anil K. ; Anderson, William F. ; Fakhry, Carole. / Epidemiology of human papillomavirus-positive head and neck squamous cell carcinoma. In: Journal of Clinical Oncology. 2015 ; Vol. 33, No. 29. pp. 3235-3242
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