Epidemiology of hepatitis E virus infection in Turkey

D. L. Thomas; T. C. Quinn; R. W. Mahley; K. E. Palaoglu; S. Badur

doi:10.1016/0140-6736(93)90698-G

Epidemiology of hepatitis E virus infection in Turkey

D. L. Thomas, T. C. Quinn, R. W. Mahley, K. E. Palaoglu, S. Badur

Johns Hopkins Hospital

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

The seroprevalence and risk factors for infection with hepatitis E virus (HEV) were analysed in five regions of Turkey, where one-third of acute hepatitis cases are non-A, non-B. Antibodies to HEV (anti-HEV) were found in 80 (5·9%) of 1350 subjects. Independent predictors of anti-HEV were age over 25 years, less than elementary education, antibodies to hepatitis C virus, and residence in the warmest region (Adana). Whereas none of 105 subjects in the second decade of life were HEV seropositive, 17 (3·7%) of 464 and 28 (9·1 %) of 308 of those in the third and fourth decades of life, respectively, had anti-HEV (p<0·001). These data demonstrate that in Turkey HEV is more prevalent in warmer regions and in adults, beginning in the third decade of life.

Original language	English (US)
Pages (from-to)	1561-1562
Number of pages	2
Journal	The Lancet
Volume	341
Issue number	8860
DOIs	https://doi.org/10.1016/0140-6736(93)90698-G
State	Published - Jun 19 1993

ASJC Scopus subject areas

General Medicine

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title = "Epidemiology of hepatitis E virus infection in Turkey",

abstract = "The seroprevalence and risk factors for infection with hepatitis E virus (HEV) were analysed in five regions of Turkey, where one-third of acute hepatitis cases are non-A, non-B. Antibodies to HEV (anti-HEV) were found in 80 (5·9%) of 1350 subjects. Independent predictors of anti-HEV were age over 25 years, less than elementary education, antibodies to hepatitis C virus, and residence in the warmest region (Adana). Whereas none of 105 subjects in the second decade of life were HEV seropositive, 17 (3·7%) of 464 and 28 (9·1 %) of 308 of those in the third and fourth decades of life, respectively, had anti-HEV (p<0·001). These data demonstrate that in Turkey HEV is more prevalent in warmer regions and in adults, beginning in the third decade of life.",

author = "Thomas, {D. L.} and Quinn, {T. C.} and Mahley, {R. W.} and Palaoglu, {K. E.} and S. Badur",

note = "Funding Information: the diagnostic assays for HEV; Dr Jill Kirby and Dr Alvaro Munoz for statistical advice; Mr George Roundtree and Dr Warren Winkler, American Bristol Hospital, Istanbul, for administrative support; and Dr Fatma Dedeoglu, University of Istanbul Faculty of Medicine, for laboratory assistance. This study was supported in part by Merck and Company.",

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AU - Quinn, T. C.

AU - Mahley, R. W.

AU - Palaoglu, K. E.

AU - Badur, S.

N1 - Funding Information: the diagnostic assays for HEV; Dr Jill Kirby and Dr Alvaro Munoz for statistical advice; Mr George Roundtree and Dr Warren Winkler, American Bristol Hospital, Istanbul, for administrative support; and Dr Fatma Dedeoglu, University of Istanbul Faculty of Medicine, for laboratory assistance. This study was supported in part by Merck and Company.

PY - 1993/6/19

Y1 - 1993/6/19

N2 - The seroprevalence and risk factors for infection with hepatitis E virus (HEV) were analysed in five regions of Turkey, where one-third of acute hepatitis cases are non-A, non-B. Antibodies to HEV (anti-HEV) were found in 80 (5·9%) of 1350 subjects. Independent predictors of anti-HEV were age over 25 years, less than elementary education, antibodies to hepatitis C virus, and residence in the warmest region (Adana). Whereas none of 105 subjects in the second decade of life were HEV seropositive, 17 (3·7%) of 464 and 28 (9·1 %) of 308 of those in the third and fourth decades of life, respectively, had anti-HEV (p<0·001). These data demonstrate that in Turkey HEV is more prevalent in warmer regions and in adults, beginning in the third decade of life.

AB - The seroprevalence and risk factors for infection with hepatitis E virus (HEV) were analysed in five regions of Turkey, where one-third of acute hepatitis cases are non-A, non-B. Antibodies to HEV (anti-HEV) were found in 80 (5·9%) of 1350 subjects. Independent predictors of anti-HEV were age over 25 years, less than elementary education, antibodies to hepatitis C virus, and residence in the warmest region (Adana). Whereas none of 105 subjects in the second decade of life were HEV seropositive, 17 (3·7%) of 464 and 28 (9·1 %) of 308 of those in the third and fourth decades of life, respectively, had anti-HEV (p<0·001). These data demonstrate that in Turkey HEV is more prevalent in warmer regions and in adults, beginning in the third decade of life.

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Epidemiology of hepatitis E virus infection in Turkey

Abstract

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